Interferon-α activates signal transducers and activators of transcription 5 and 6 in Daudi cells
Interferon-α activates signal transducers and activators of transcription 5 and 6 in Daudi cells
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DOI：
10.1046/j.1432-1327.1998.2540514.x
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发表时间：
1998-06-15
期刊：
影响因子：
--
通讯作者：
Heim, H
中科院分区：
文献类型：
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作者：
Fasler-Kan, E;Pansky, A;Heim, H
在目前研究的大多数细胞中，干扰素-α(干扰素-α)可激活信号转导和转录激活因子(STAT1)、STAT2和STAT3，而干扰素-γ(干扰素-γ)仅能诱导STAT1。一般来说，几十种细胞因子、生长因子和激素中的每一种都通过Janus激酶-信号转导和转录激活因子(JAK-STAT)途径发出信号，激活一组不同的STATs，这种选择性被认为是细胞对这些配体的特异性反应所必需的。在这里，我们研究了人类淋巴母细胞系Daudi对干扰素-α的反应中STAT的激活模式。除了STAT1、STAT2和STAT3的激活外，干扰素-α还可以直接诱导STAT5和STAT6的激活。额外STATS的细胞类型特异性激活可能是对干扰素-α的细胞类型特异性反应的原因。
In most cells studied so far, interferon-alpha (IFN-alpha) activates signal transducer and activator of transcription (Stat1), Stat2 and Stat3, whereas interferon-gamma (IFN-gamma) induces Stat1 only. In general, each of the several dozens of cytokines, growth factors and hormones that signal through the Janus kinases-signal transducers and activators of transcription (Jak-STAT) pathway activates a distinct subset of STATs, and this selectivity is thought to be essential for the specificity of the cellular responses toward these ligands. Here, we have studied the pattern of STAT activation in the human lymphoblastoid cell line Daudi in response to IFN-alpha. In addition to Stat1, Stat2 and Stat3 activation, IFN-alpha was found to directly induce activation of Stat5 and Stat6. Cell-type-specific activation of additional STATs could be responsible for cell-type-specific responses to IFN-alpha.