Clinical implications of Brief Psychiatric Rating Scale scores
Clinical implications of Brief Psychiatric Rating Scale scores
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DOI：
10.1192/bjp.187.4.366
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发表时间：
2005-10-01
影响因子：
10.5
通讯作者：
Engel, R
中科院分区：
文献类型：
--
作者：
Leucht, S;Kane, JM;Engel, R
背景尽管简明精神病评定量表（BPRS）被广泛使用，但其总分和用于定义治疗反应的截断值的临床意义尚不清楚。方法对1979例急性期精神分裂症患者的7个药物试验的BPRS和CGI评分进行等百分位数连接结果CGI评定的BPRS总分为31分为“轻度”，BPRS总分为41分为“中度”，BPRS总分为53分为“重度”。根据CGI评分，“最小改善”与第1、2和4周BPRS降低百分比分别为24、27和30%相关。结论本研究结果为临床试验中如何解释BPRS总分和减分百分比提供了更清晰的理解，这些临床试验中的急性精神分裂症患者有阳性症状。资金详情见鸣谢。
Background Despite the widespread use of the Brief Psychiatric Rating Scale (BPRS), the clinical meaning of its total score and cut-off values used to define treatment response are unclear.Aims To link the BPRS to Clinical Global Impression (CGI) ratings,Method Equipercentile linking of BPRS and CGI ratings from seven drug trials in acutely ill patients with schizophrenia (n=1979).Results 'Mildly ill' according to the CGI approximately corresponded to a BPRS total score of 31,'moderately ill' to a BPRS score of 41 and' markedly ill' to a BPRS score of 53. 'Minimally improved' according to the CGI score was associated with percentage BPRS reductions of 24, 27 and 30% at weeks 1, 2 and 4, respectively The corresponding numbers for a CGI rating of. much improved' were 44,53 and 58%.Conclusions The results provide a clearer understanding of how to interpret BPRS total and percentage reduction scores in clinical trials with patients acutely ill with schizophrenia who are experiencing positive symptoms.Declaration of interest None. Funding detailed in Acknowledgements.