Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies.
Effects of blood triglycerides on cardiovascular and all-cause mortality: a systematic review and meta-analysis of 61 prospective studies.
复制标题
血液甘油三酯对心血管和全因死亡率的影响：对 61 项前瞻性研究的系统回顾和荟萃分析
DOI：
10.1186/1476-511x-12-159
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发表时间：
2013-10-29
影响因子：
4.5
通讯作者：
Chen YM
中科院分区：
文献类型：
--
作者：
Liu J;Zeng FF;Liu ZM;Zhang CX;Ling WH;Chen YM
甘油三酯（TG）与死亡风险的关系仍不确定。本研究的目的是确定血甘油三酯水平与心血管疾病（CVD）死亡率和全因死亡率之间的关系。在无语言限制的情况下检索了4个数据库的相关研究：PubMed、ScienceDirect、EMBASE和Google Scholar。纳入了2013年7月之前发表的所有报告TG与CVD或全因死亡率之间相关性的前瞻性队列研究。根据TG类别、TG单位和TG对数，使用具有逆方差加权的随机效应模型提取并合并风险比（RR）和95%置信区间（CI）。我们确定了61项合格的研究，其中726，030名参与者中有17，018例心血管疾病死亡，330，566名参与者中有58，419例全因死亡。分别有12项和14项研究报告了按TG分类的CVD和总死亡率的效应估计值。与所指对象相比（90-149 mg/dL），心血管疾病死亡率最低的合并RR（95% CI）（< 90 mg/dL），临界高（150-199 mg/dL）和高TG（≥ 200 mg/dL）组为0.83（0.75至0.93），1.15总死亡率分别为0.94（0.85 ~ 1.03）、1.09（1.02 ~ 1.17）和1.20（1.04 ~ 1.38）。在22项和22项研究中，报告了每单位TG的RR，每增加1 mmol/L TG，心血管疾病和全因死亡的风险分别增加13%和12%（p < 0.001）。总之，血TG水平升高与心血管疾病风险和全因死亡率升高呈剂量依赖性相关。
The relationship of triglycerides (TG) to the risk of death remains uncertain. The aim of this study was to determine the associations between blood triglyceride levels and cardiovascular diseases (CVDs) mortality and all-cause mortality. Four databases were searched without language restriction for relevant studies: PubMed, ScienceDirect, EMBASE, and Google Scholar. All prospective cohort studies reporting an association between TG and CVDs or all-cause mortality published before July 2013 were included. Risk ratios (RRs) with 95% confidence intervals (CIs) were extracted and pooled according to TG categories, unit TG, and logarithm of TG using a random-effects model with inverse-variance weighting. We identified 61 eligible studies, containing 17,018 CVDs deaths in 726,030 participants and 58,419 all-cause deaths in 330,566 participants. Twelve and fourteen studies, respectively, reported the effects estimates of CVDs and total mortality by TG categories. Compared to the referent (90–149 mg/dL), the pooled RRs (95% CI) of CVDs mortality for the lowest (< 90 mg/dL), borderline-high (150–199 mg/dL), and high TG (≥ 200 mg/dL) groups were 0.83 (0.75 to 0.93), 1.15 (1.03 to 1.29), and 1.25 (1.05 to 1.50); for total mortality they were 0.94 (0.85 to 1.03), 1.09 (1.02 to 1.17), and 1.20 (1.04 to 1.38), respectively. The risks of CVDs and all-cause deaths were increased by 13% and 12% (p < 0.001) per 1-mmol/L TG increment in twenty-two and twenty-two studies reported RRs per unit TG, respectively. In conclusion, elevated blood TG levels were dose-dependently associated with higher risks of CVDs and all-cause mortality.