Gene therapy for gastric diseases.
Gene therapy for gastric diseases.
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DOI：
10.2174/156652308784746431
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发表时间：
2008-05
影响因子：
3.6
通讯作者：
S. Fumoto;Junya Nishi;J. Nakamura;K. Nishida
中科院分区：
文献类型：
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作者：
S. Fumoto;Junya Nishi;J. Nakamura;K. Nishida
胃癌和胃溃疡的基因治疗是一种合理的策略，因为这些疾病与多种基因相关。由于在非靶组织/细胞中的基因表达会产生副作用，因此必须开发一种针对胃癌和/或癌症的选择性基因递送系统。载体转移的途径(直接注射、全身、腹腔、胃浆膜表面和口服给药)是决定疗效和安全性的重要问题。肿瘤基因治疗的策略可分为自杀基因治疗、抑制生长和诱导细胞凋亡、免疫治疗、抗血管生成等。靶基因与其他基因和/或策略的结合，如化疗和病毒治疗，是很有希望的。治疗胃溃疡的候选药物有血管内皮生长因子、血管生成素-1、血清反应因子和阳离子宿主防御肽。在本文中，我们讨论了以胃和癌症为靶点的基因转移方法，并总结了针对胃癌和胃溃疡的基因治疗试验。
Gene therapy for gastric cancer and gastric ulcer is a rationalized strategy since various genes correlate with these diseases. Since gene expressions in non-target tissues/cells cause side effects, a selective gene delivery system targeted to the stomach and/or cancer must be developed. The route of vector transfer (direct injection, systemic, intraperitoneal, gastric serosal surface and oral administration) is an important issue which can determine efficacy and safety. Strategies for cancer gene therapy can be categorized as suicide gene therapy, growth inhibition and apoptosis induction, immunotherapy, anti-angiogenesis, and others. Combination of the target gene with other genes and/or strategies such as chemotherapy and virotherapy is promising. Candidates for treatment of gastric ulcer are vascular endothelial growth factor, angiopoietin-1, serum response factor, and cationic host defense peptide cathelicidin. In this review, we discuss stomach- and cancer-targeted gene transfer methods and summarize gene therapy trials for gastric cancer and gastric ulcer.