Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan.
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan.
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DOI：
10.1016/j.cmet.2016.06.001
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发表时间：
2016-06-14
期刊：
影响因子：
29
通讯作者：
Panda S
中科院分区：
文献类型：
--
作者：
Longo VD;Panda S
大多数动物的进食被限制在一个特定的时间段，留下与睡眠时间重合的短暂禁食期。禁食使生物体能够进入其他代谢阶段，这些阶段对葡萄糖的依赖减少，而对类似酮体的碳源依赖增加。间歇性禁食和周期性禁食都能带来从预防到疾病强化治疗等一系列益处。同样，限时进食（TRF），即进食时间被限制在一天中的特定几个小时，使得每日禁食时间持续>12小时，从而在多种生物体中产生多效性益处。了解营养物质与禁食益处之间的机制联系，正促使人们确定模拟禁食饮食（FMDs），这种饮食能实现与禁食相似的变化。鉴于限时进食和模拟禁食饮食具有多效性和持续性的益处，有必要开展基础科学和转化研究，将与禁食相关的干预措施发展成为有效且廉价的治疗方法，有可能改善健康寿命。
Feeding in most animals is confined to a defined period, leaving short periods of fasting that coincide with sleep. Fasting enables organisms to enter alternative metabolic phases, which rely less on glucose and more on ketone body-like carbon sources. Both intermittent and periodic fasting result in benefits ranging from prevention to the enhanced treatment of diseases. Similarly, time-restricted feeding (TRF), in which feeding time is restricted to certain hours of the day, allows the daily fasting period to last >12 h, thus imparting pleiotropic benefits in multiple organisms. Understanding the mechanistic link between nutrients and the fasting benefits is leading to the identification of fasting mimicking diets (FMDs) that achieve changes similar to those caused by fasting. Given the pleiotropic and sustained benefits of TRF and FMD, both basic science and translational research are warranted to develop fasting-associated interventions into effective and inexpensive treatments with the potential to improve healthspan.