Immune regulation: A critical link between NK cells and CTLs
Immune regulation: A critical link between NK cells and CTLs
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DOI：
10.1016/0167-5699(96)80616-5
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发表时间：
1996-04-01
期刊：
影响因子：
--
通讯作者：
Engleman, EG
中科院分区：
文献类型：
--
作者：
Kos, FJ;Engleman, EG
对病原体的免疫应答通常涉及从先天免疫到适应性免疫的进展。先天免疫是否以及如何影响适应性免疫，反之亦然的问题仍然在很大程度上未被探索。在这里，Ferdyland科斯和埃德加恩格勒曼提出，自然杀伤（NK）细胞和细胞毒性T淋巴细胞（CTL）调节彼此的功能，从而控制免疫反应的结果。
An immune response to pathogen typically involves progression from innate immunity to adaptive immunity. The questions of whether and how innate immunity influences adaptive immunity and vice versa are still largely unexplored. Here, Ferdynand Kos and Edgar Engleman propose that natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) regulate the functions of each other, thereby controlling the outcome of an immune response.