Protein Tyrosine Phosphatases: A new paradigm in an old signaling system?
Protein Tyrosine Phosphatases: A new paradigm in an old signaling system?
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DOI：
10.1016/bs.acr.2021.06.001
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发表时间：
2021
影响因子：
--
通讯作者：
Ahuja, Lalima G.
中科院分区：
文献类型：
--
作者：
Welsh, Colin L.;Pandey, Preeti;Ahuja, Lalima G.
蛋白酪氨酸磷酸酶通过使靶蛋白上的磷酸酪氨酸去磷酸化来逆转由生长因子受体和其他酪氨酸激酶启动的细胞信号。这些酶的活性对于维持细胞内环境的稳定至关重要，然而这些酶经常被认为是不起眼的看家蛋白质。可以理解的是，蛋白酪氨酸磷酸酶的突变和表达模式的变化与肿瘤的发生和各种癌症有关。其催化域的保守性使药物发现成为一项具有挑战性的工作。在这篇综述中，我们重点描述了蛋白质酪氨酸磷酸酶的各类及其催化结构域。我们还以特定成员为模型系统，总结了它们在癌症和神经退行性疾病中的作用。最后，我们解释了蛋白酪氨酸磷酸酶的催化活性和假酶形式在其膜结合受体形式方面的生物学作用的二分法。本章旨在提供对这些蛋白质的最新了解，在它们过去的基础研究的背景下。
Protein Tyrosine Phosphatases reverse cellular signals initiated by growth factors receptors and other tyrosine kinases by dephosphorylating phosphotyrosine on target proteins. The activity of these enzymes is crucial for maintaining cell homeostasis, yet these enzymes have been often dismissed as humble house-keeping proteins. Understandably, mutations and changes in expression patterns of Protein Tyrosine Phosphatases are implicated in tumorigenesis and various carcinomas. The conserved nature of their catalytic domains makes drug discovery a challenging pursuit. In this review we focus on describing the various classes of Protein Tyrosine Phosphatases and their catalytic domains. We also summarize their role in cancer and neurodegenerative disease using specific members as the model system. Finally, we explain the dichotomy in the biological role of catalytically active versus the pseudoenzyme forms of Protein Tyrosine Phosphatases in the context of their membrane bound receptor forms. This chapter aims to provide a current understanding of these proteins, in the background of their foundational past research.
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影响因子：
4.8
作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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影响因子：
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作者：
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