Plasma Phospholipid Fatty Acid Content Is Related to Disease Activity in Ankylosing Spondylitis
Plasma Phospholipid Fatty Acid Content Is Related to Disease Activity in Ankylosing Spondylitis
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DOI：
10.3899/jrheum.110575
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发表时间：
2012-02-01
影响因子：
3.9
通讯作者：
Wallberg-Jonsson, Solveig
中科院分区：
文献类型：
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作者：
Sundstrom, Bjorn;Johansson, Gunnar;Wallberg-Jonsson, Solveig
目标。在一项横断面研究中，研究强直性脊柱炎（AS）患者饮食中的脂肪酸组成、血浆磷脂和脂肪组织，并确定它们与疾病活动性和血脂的相关性。采用食物频率问卷对66例AS患者的饮食进行评估。用气相色谱法测定血浆磷脂和臀脂肪组织中的多不饱和脂肪酸。采用巴斯强直性脊柱炎疾病活动指数（BASDAI）、红细胞沉降率（ESR）、高敏c反应蛋白和促炎细胞因子对疾病状态进行量化。饮食与BASDAI评估的疾病活动度无相关性，但饮食摄入长链omega-3脂肪酸与ESR呈负相关（r(s) = -0.27, p < 0.05）。花生四烯酸血浆磷脂含量与BASDAI评分呈极显著相关（r(s) = 0.39, p < 0.01）。长链ω -3脂肪酸摄入量与高密度脂蛋白和血清甘油三酯之间存在相关性(r（s) = 0.26, r(s) = -0.25, p < 0.05）。AS患者血浆磷脂中花生四烯酸水平与BASDAI评估的疾病活动性呈正相关。西方饮食似乎不影响这种相关性，但似乎影响了参与动脉粥样硬化过程的血脂。（首次发布2011年12月15日；J Rheumatol 2012;39:327-33; doi:10.3899/ jrheumat. 110575）
Objective. To investigate fatty acid composition in the diet, plasma phospholipids, and adipose tissue in a cohort of patients with ankylosing spondylitis (AS), and to determine their correlations to disease activity and blood lipids in a cross-sectional study.Methods. Diet was assessed using a food frequency questionnaire in 66 patients with AS. Polyunsaturated fatty acids in plasma phospholipids and gluteal adipose tissue were measured using gas chromatography. Disease status was quantified using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein, and proinflammatory cytokines.Results. Diet did not correlate with disease activity assessed by the BASDAI, but there were negative correlations between the dietary intake of long-chain omega-3 fatty acids and ESR (r(s) = -0.27, p < 0.05). The plasma phospholipid content of arachidonic acid correlated significantly with the BASDAI score (r(s) = 0.39, p < 0.01). There were correlations between the intake of long-chain omega-3 fatty acids and high-density lipoproteins and serum triglycerides (r(s) = 0.26 and r(s) = -0.25, respectively, p < 0.05).Conclusion. There was a positive correlation between levels of arachidonic acid in plasma phospholipids and disease activity assessed by BASDAI in patients with AS. A Western diet does not appear to influence this correlation, but seems to affect blood lipids involved in atherogenic processes. (First Release Dec 15 2011; J Rheumatol 2012;39:327-33; doi:10.3899/jrheum.110575)