A measure of explained risk in the proportional hazards model
A measure of explained risk in the proportional hazards model
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DOI：
10.1093/biostatistics/kxr047
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发表时间：
2012-04-01
期刊：
影响因子：
2.1
通讯作者：
Heller, Glenn
中科院分区：
文献类型：
--
作者：
Heller, Glenn
开发了一种解释风险的度量，用于比例风险模型的应用。该统计数据称为估计解释相对风险，具有简单的分析形式，并且不受审查的影响，审查与协变量条件下的生存时间无关。推导了估计解释相对风险极限值的渐近置信区间，并建立了各个因素在其估计计算中的作用。进行模拟以将估计的解释相对风险的结果与具有审查数据的其他已知解释风险度量进行比较。前列腺癌数据用于证明结合所提出的方法的分析。
A measure of explained risk is developed for application with the proportional hazards model. The statistic, which is called the estimated explained relative risk, has a simple analytical form and is unaffected by censoring that is independent of survival time conditional on the covariates. An asymptotic confidence interval for the limiting value of the estimated explained relative risk is derived, and the role of individual factors in the computation of its estimate is established. Simulations are performed to compare the results of the estimated explained relative risk to other known explained risk measures with censored data. Prostate cancer data are used to demonstrate an analysis incorporating the proposed approach.