Bone morphogenetic protein-7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor
Bone morphogenetic protein-7 increases thrombogenicity of lipid-rich atherosclerotic plaques via activation of tissue factor
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DOI：
10.1016/j.thromres.2010.06.026
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发表时间：
2010-10-01
影响因子：
7.5
通讯作者：
Hansen, J. B.
中科院分区：
文献类型：
--
作者：
Sovershaev, M. A.;Egorina, E. M.;Hansen, J. B.
动脉粥样硬化斑块的血栓形成性很大程度上取决于斑块的形态。组织因子（TF）在富含脂质的病变中的表达高于钙化病变。虽然骨形态发生蛋白(BMP) -7是一种已知的血管钙化抑制剂，但BMP-7在斑块血栓形成中的作用尚不确定。我们假设富脂斑块的血栓形成潜力增加归因于BMP-7激活TF。我们测量了富含脂质和钙化的颈动脉斑块中BMP-7和TF蛋白的水平，并在体外测试了BMP-7对人单核细胞中TF表达的影响。对动脉内膜切除术标本进行TF和BMP-7的定量免疫组化分析显示，富脂斑块比钙化斑块含有更多的TF抗原(158.6 +/- 25.3 AU vs 37.4 +/- 8.8 AU, p
Thrombogenicity of atherosclerotic plaques largely depends on plaque morphology. Tissue factor (TF) expression is higher in lipid-rich than in calcified lesions. Although bone morphogenetic protein (BMP) -7 is a known inhibitor of vascular calcification, the role of BMP-7 in the development of plaque thrombogenicity is uncertain. We hypothesized that increased thrombogenic potential of lipid-rich plaques is attributed to activation of TF by BMP-7. We measured levels of BMP-7 and TF proteins in lipid-rich and calcified carotid plaques, and tested the effects of BMP-7 on TF expression in human monocytes in vitro. Quantitative immunohistochemical analysis of endarterectomy specimens for TF and BMP-7 revealed that lipid-rich plaques contained more TF antigen than calcified ones (158.6 +/- 25.3 vs 37.4 +/- 8.8 AU, p