Copper-catalyzed decarboxylative cross-coupling of cinnamic acids and ACCN via single electron transfer
Copper-catalyzed decarboxylative cross-coupling of cinnamic acids and ACCN via single electron transfer
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铜催化肉桂酸和 ACCN 通过单电子转移脱羧交叉偶联
DOI：
10.1039/c5ob02677f
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发表时间：
2016-01-01
影响因子：
3.2
通讯作者：
Huang, Hanmin
中科院分区：
文献类型：
--
作者：
Gao, Bao;Xie, Yinjun;Huang, Hanmin
介绍了一种以1，1‘-偶氮二环己烷-1-碳腈为氰基原料合成β，γ-不饱和腈的新方法。该反应的底物范围很广，通过单电子转移和脱羧基反应，以中等的产率和高的选择性提供了所需的含有全碳季碳中心的β，伽马不饱和腈。
A novel and convenient method for the synthesis of beta,gamma-unsaturated nitriles using ACCN (1,1'-azobis(cyclohexane-1-carbonitrile)) as a cyano source was described. This reaction was amenable to a broad range of substrates and provided the desired beta,gamma-unsaturated nitriles containing an all-carbon quaternary carbon center in moderate yields with high selectivity via single electron transfer and decarboxylation.