Chronic Thyroiditis in the Rabbit Induced with Homologous Thyroid Microsomes
Chronic Thyroiditis in the Rabbit Induced with Homologous Thyroid Microsomes
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同源甲状腺微粒体诱发家兔慢性甲状腺炎
DOI：
10.1126/science.178.4058.316
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发表时间：
1972
期刊：
影响因子：
56.9
通讯作者：
H. Battifora
中科院分区：
文献类型：
--
作者：
M. Mangkornkanok;A. Markowitz;H. Battifora
用新鲜分离的同种甲状腺微粒体在完全弗氏佐剂中免疫的家兔发生了严重的慢性甲状腺炎，伴随着抗微粒体抗体的产生。采用分离的微粒体作为抗原，通过间接免疫荧光和补体结合测定抗体应答。微粒体能吸收兔血清的免疫活性，但甲状腺球蛋白不能。
Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, employing isolated microsomes as the antigen. Microsomes but not thyroglobulin absorbed out the immunologic activity of the rabbit serum.