CT imaging for the investigation of subchondral bone in knee osteoarthritis
CT imaging for the investigation of subchondral bone in knee osteoarthritis
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DOI：
10.1007/s00198-012-2169-5
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发表时间：
2012-12-01
影响因子：
4
通讯作者：
Laredo, J. -D.
中科院分区：
文献类型：
--
作者：
Bousson, V.;Lowitz, T.;Laredo, J. -D.
在骨关节炎中，磁共振成像是关节软骨和骨髓病变成像的首选方法。然而，钙化软骨、软骨下骨板和软骨下骨小梁是矿化组织，它们强烈地减弱了X射线，因此可能可以使用计算机断层扫描（CT）进行分析。CT图像很好地显示了晚期骨关节炎的骨性主要征象，如骨赘、软骨下囊肿和软骨下骨硬化。但更重要的是，CT可以帮助我们从测量体内软骨下矿化组织的密度和结构来更好地了解膝关节骨关节炎的病理生理学。为此，我们最近开发了专用的图像分析软件，称为医学图像分析框架（MIAF）-膝关节。在这篇手稿中，我们的目的是介绍膝关节骨关节炎中软骨下骨CT成像的现有知识，并简要介绍MIAF-膝关节的基本技术方面以及我们在膝关节骨关节炎患者中获得的与对照受试者相比的初步结果。
In osteoarthritis, magnetic resonance imaging is the method of choice to image articular cartilage and "bone marrow lesions." However, the calcified cartilage, the subchondral bone plate, and trabecular subchondral bone that are mineralized tissues strongly attenuate X-rays and are therefore potentially accessible for analyses using computed tomography (CT). CT images nicely show osseous cardinal signs of advanced osteoarthritis such as osteophytes, subchondral cysts, and subchondral bone sclerosis. But more importantly, CT can help us to better understand the pathophysiology of knee osteoarthritis from the measurement of the density and structure of subchondral mineralized tissues in vivo. For that purpose, we recently developed dedicated image analysis software called Medical Image Analysis Framework (MIAF)-Knee. In this manuscript, our aims are to present current knowledge on CT imaging of the subchondral bone in knee osteoarthritis and to provide a brief introduction to basic technical aspects of MIAF-Knee as well as preliminary results we obtained in patients with knee osteoarthritis as compared to control subjects.