Nonenzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst
Nonenzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst
复制标题
DOI：
10.1055/s-2008-1032057
复制
发表时间：
2008-02-12
期刊：
影响因子：
2
通讯作者：
Onomura, Osamu
中科院分区：
文献类型：
--
作者：
Demizu, Yosuke;Kubo, Yuki;Onomura, Osamu
以三氟甲磺酸铜（II）和（R，R）-PhBox [2，2 '-异亚丙基双（4-苯基-2-恶唑啉）]为催化剂，通过苯甲酰化反应实现了3-羟基烷酰胺的高选择性动力学拆分，并高效介导了2，2-双（羟甲基）烷酰胺的对映选择性对甲苯磺酰化反应.
Kinetic resolution of 3-hydroxyalkanamides with good to high selectivities was achieved by benzoylation using copper(II) triflate and (R,R)-PhBox [2,2'-isopropylidenebis(4-phenyl-2-oxazoline)] as catalyst, which also mediated enantioselective tosylation of 2,2-bis(hydroxymethyl)alkanamides with high efficiency.