High-resolution mapping of iso-orientation columns by fMRI
High-resolution mapping of iso-orientation columns by fMRI
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DOI：
10.1038/72109
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发表时间：
2000-02-01
影响因子：
25
通讯作者：
Kim, SG
中科院分区：
文献类型：
--
作者：
Kim, DS;Duong, TQ;Kim, SG
血氧水平依赖（BOLD）功能磁共振成像（fMRI）是在体定位脑功能的重要工具。然而，BOLD功能磁共振成像映射皮质柱状结构的能力是非常有争议的，因为BOLD的最终功能特异性仍然未知。在这里，我们报告了一个双相BOLD反应的视觉刺激在初级视觉皮层的猫。在功能成像中，初始BOLD信号减少，精确标记了各个等取向柱。与此相反，延迟的正BOLD变化表明在视觉皮层的整体激活模式，但不太适合区分活跃的非活跃列。
Blood-oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is an important tool for localizing brain functions in vivo. However, the ability of BOLD fMRI to map cortical columnar structures is highly controversial, as the ultimate functional specificity of BOLD remains unknown. Here we report a biphasic BOLD response to visual stimulation in the primary visual cortex of cats. In functional imaging, the initial BOLD signal decrease accurately labeled individual iso-orientation columns. In contrast, the delayed positive BOLD changes indicated the pattern of overall activation in the visual cortex, but were less suited to discriminate active from inactive columns.