Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy.
Pomegranate extract inhibits the bone metastatic growth of human prostate cancer cells and enhances the in vivo efficacy of docetaxel chemotherapy.
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石榴提取物抑制人前列腺癌细胞的骨转移生长，增强多西紫杉醇化疗的体内疗效。
DOI：
10.1002/pros.22769
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Wu,Daqing
中科院分区：
文献类型：
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作者：
Wang,Yanru;Zhang,Shumin;Iqbal,Shareen;Chen,Zhengjia;Wang,Xiaojing;Wang,YongqiangA;Liu,David;Bai,Kevin;Ritenour,Chad;Kucuk,Omer;Wu,Daqing
Docetrin治疗是转移性去势抵抗性前列腺癌（PCa）中唯一具有生存益处的一线化疗。尽管如此，大多数患者对多西他赛产生耐药性，并且不可避免地进展而无法治愈。在这项研究中，我们研究了石榴提取物（PE）在靶向转移性去势抵抗性PCa和改善多西他赛chemotherapy.METHODSThe在体外和体内的影响POMx，目前批准用于临床试验的PE配方，在转移性去势抵抗性PCa细胞进行了评估，在实验models. ORTSWe表明，POMx在转移性去势抵抗性PCa细胞中表现出强有力的体外细胞毒性。机制研究确定生存素是一种新的分子靶点，可能通过抑制信号转导和转录激活因子3介导POMx的抗癌活性。POMx治疗的体内施用有效地抑制存活素，诱导细胞凋亡，延缓骨骼中的C4 - 2肿瘤生长，并显著增强多西他赛在无胸腺裸鼠中的功效。CONCLUSION这些结果提供了第一个临床前证据，即POMx可能有效地治疗转移性去势抵抗性PCa并增强多西他赛化疗的功效。Prostate 74：497-508，2014。© 2013 Wiley Periodicals，Inc.
BACKGROUNDDocetaxel treatment is the only first‐line chemotherapy with a survival benefit in metastatic castration‐resistant prostate cancer (PCa). Nonetheless, most patients become docetaxel resistant and inevitably progress with no cure. In this study, we investigated the potential of pomegranate extract (PE) in targeting metastatic castration‐resistant PCa and improving docetaxel chemotherapy.METHODSThe in vitro and in vivo effect of POMx, a PE formula currently approved for clinical trials, in metastatic castration‐resistant PCa cells was evaluated in experimental models.RESULTSWe demonstrated that POMx exhibited potent in vitro cytotoxicity in metastatic castration‐resistant PCa cells. Mechanistic studies identified survivin as a novel molecular target that may mediate the anti‐cancer activity of POMx, presumably through the inhibition of signal transducer and activator of transcription 3. The in vivo administration of POMx treatment effectively inhibited survivin, induced apoptosis, retarded C4‐2 tumor growth in skeleton and significantly enhanced the efficacy of docetaxel in athymic nude mice.CONCLUSIONThese results provide the first preclinical evidence that POMx may be effective in treating metastatic castration‐resistant PCa and enhancing the efficacy of docetaxel chemotherapy.Prostate 74:497–508, 2014. © 2013 Wiley Periodicals, Inc.