Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion
Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion
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DOI：
10.1002/jcb.24518
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发表时间：
2013-08-01
影响因子：
4
通讯作者：
Morrison, Nigel A.
中科院分区：
文献类型：
--
作者：
Khan, Usman A.;Hashimi, Saeed M.;Morrison, Nigel A.
巨噬细胞具有融合并形成多核巨细胞的能力，例如破骨细胞（OC）和FBGC。破骨细胞刺激跨膜蛋白（OC-STAMP）是参与破骨细胞形成的重要细胞表面蛋白。本研究试图通过表达分析和随后的抑制研究来确定 OC-STAMP 是否也调节 FBGC 的形成。 qPCR 和 Western blot 分析表明，与对照单核细胞相比，FBGC 中 OC-STAMP 的表达显着升高（P
Macrophages have the ability to fuse and form multinucleated giant cells such as Osteoclast (OCs) and FBGCs. Osteoclast stimulatory transmembrane protein (OC-STAMP) is an important cell surface protein involved in the formation of OCs. This study sought to determine if OC-STAMP also regulates formation of FBGCs using expression analysis and subsequent inhibition studies. qPCR and Western blot analysis showed that OC-STAMP expression is significantly higher in FBGCs compared to control monocytes (P