Timing of colonization of caries-producing bacteria: an approach based on studying monozygotic twin pairs.
Timing of colonization of caries-producing bacteria: an approach based on studying monozygotic twin pairs.
复制标题
产生龋齿的细菌定植的时机：基于研究单卵双胞胎对的方法。
DOI：
10.1155/2011/571573
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发表时间：
2011
影响因子：
2.1
通讯作者：
Townsend GC
中科院分区：
文献类型：
--
作者：
Bockmann MR;Harris AV;Bennett CN;Odeh R;Hughes TE;Townsend GC
研究结果来自一项前瞻性队列研究，研究对象是澳大利亚双胞胎的乳牙出现时间和变形链球菌（S. mutans）口腔定植时间。本文主要研究了遗传上相同的单卵（MZ）双胞胎在定植时间上的差异。出牙时间以父母报告为准。通过将菌斑和唾液样品每隔3个月在选择性培养基上镀一次，并评估菌落形态，确定变形链球菌的定植时间。在25%的个体中，植牙发生在第一颗牙齿出现之前。很大比例的MZ对（21%）在第一颗牙齿出现之前或之后的定植不一致，这表明环境或表观遗传因素在牙齿出现的时间，变形链球菌的定植，或两者的作用。这些发现以及MZ同卵双胞胎模型的进一步应用将有助于制定预防或延迟儿童变形链球菌感染的策略。
Findings are presented from a prospective cohort study of timing of primary tooth emergence and timing of oral colonization of Streptococcus mutans (S. mutans) in Australian twins. The paper focuses on differences in colonization timing in genetically identical monozygotic (MZ) twins. Timing of tooth emergence was based on parental report. Colonization timing of S. mutans were established by plating samples of plaque and saliva on selective media at 3 monthly intervals and assessing colony morphology. In 25% of individuals colonization occurred prior to emergence of the first tooth. A significant proportion of MZ pairs (21%) was discordant for colonization occurring before or after first tooth emergence, suggesting a role of environmental or epigenetic factors in timing of tooth emergence, colonization by S. mutans, or both. These findings and further application of the MZ co-twin model should assist in development of strategies to prevent or delay infection with S. mutans in children.