Slow variable dominance and phase resetting in phantom bursting.
Slow variable dominance and phase resetting in phantom bursting.
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DOI：
10.1016/j.jtbi.2011.01.042
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发表时间：
2011-05-07
影响因子：
2
通讯作者：
Bertram R
中科院分区：
文献类型：
--
作者：
Watts M;Tabak J;Zimliki C;Sherman A;Bertram R
爆发振荡在神经元和内分泌细胞中很常见。一种具有两个慢变量的突发模型被称为“幻影突发”，因为突发周期是慢变量的时间常数的混合。幻象爆发模型可以产生具有广泛周期的爆发：快速（短周期）、中等和慢速（长周期）。我们描述了一个措施，我们称之为“主导因素”，两个慢变量的相对贡献的爆发产生一个简单的幻影爆发模型。使用这个工具，我们演示了如何控制不同阶段的突发可以从一个慢变量转移到另一个通过改变模型参数。然后，我们表明，作为一个参数得到的优势曲线是不同的，可以是有用的模型细胞的复位性能的预测。最后，我们展示了两种机制，通过这两种机制可以实现突发的相位无关的重置，正如已经证明的那样，发生在胰岛的电活动中。
Bursting oscillations are common in neurons and endocrine cells. One type of bursting model with two slow variables has been called ‘phantom bursting’ since the burst period is a blend of the time constants of the slow variables. A phantom bursting model can produce bursting with a wide range of periods: fast (short period), medium, and slow (long period). We describe a measure, which we call the ‘dominance factor’, of the relative contributions of the two slow variables to the bursting produced by a simple phantom bursting model. Using this tool, we demonstrate how the control of different phases of the burst can be shifted from one slow variable to another by changing a model parameter. We then show that the dominance curves obtained as a parameter is varied can be useful in making predictions about the resetting properties of the model cells. Finally, we demonstrate two mechanisms by which phase-independent resetting of a burst can be achieved, as has been shown to occur in the electrical activity of pancreatic islets.