Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood)
Anti-ulcer activity of crude alcoholic extract of Toona ciliata Roemer (heart wood)
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DOI：
10.1016/j.jep.2006.10.018
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发表时间：
2007-03-21
影响因子：
5.4
通讯作者：
Kavimani, S.
中科院分区：
文献类型：
--
作者：
Malairajan, P.;Gopalakrishnan, Geetha;Kavimani, S.
评价了红椿乙醇提取物（心材）对阿司匹林加幽门结扎诱导的胃溃疡（抗分泌）、盐酸乙醇诱导的溃疡（细胞保护）和水浸应激诱导的大鼠溃疡的抗溃疡活性。我们发现300 mg/kg p.o.显著降低所有三种模型的溃疡发生率。红椿醇提物能显著降低胃容积、游离酸、总酸和溃疡指数。植物提取物也显示出胃保护活性（52.94%），而标准药物硫糖铝显示94.85%。红椿提取物对水浸应激性溃疡的保护指数为43.0%，而标准药物奥奈拉唑的保护指数为100%。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The ethanol extract of Toona ciliata Roemer (heart wood) was evaluated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer (anti secretory), HCI-ethanol induced ulcer (cytoprotective) and water immersion stress induced ulcer in rats. We found that Toona ciliata extract at a dose of 300 mg/kg p.o. markedly decrease the incidence of ulcers in all the three models. Ethanol extract of Toona ciliata showed significant reduction in gastric volume, free acidity, total acidity and ulcer index. The plant extract also showed gastro protective activity (52.94%), whereas standard drug sucralfate showed 94.85%. Toona ciliata extract showed protection index 43.0% in water immersion stress induced ulcer, whereas standard drug orneprazole showed protection index 100%. (c) 2006 Elsevier Ireland Ltd. All rights reserved.