Multiple primary cancer incidence in Italy
Multiple primary cancer incidence in Italy
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DOI：
10.1016/s0959-8049(01)00314-8
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发表时间：
2001-12-01
影响因子：
8.4
通讯作者：
Falini, P
中科院分区：
文献类型：
--
作者：
Crocetti, E;Buiatti, E;Falini, P
从 11 个意大利人口癌症登记处（总人口 720 万居民）收集的数据用于计算 15 岁或以上癌症患者队列中第二独立癌症 (MP) 的发病率。总体而言，对 240 111 名患者进行了 544 438 人年的随访，期间诊断出 8766 例第二原发癌，导致 MP 的观察与预期比率 (SIR) 为 1.08（95% 置信区间 (CI)：1.05-1.12）。将分析限制在异时性癌症上，在 508,648 人年的 198,303 名患者中诊断出 6974 例第二原发性癌症，SIR 为 0.93（95% CI：0.90-0.96）。根据首次癌症诊断以来的时间，前 2 个月的 SIR 显着高于预期，诊断后 1 至 10 年内总体风险略低于 1。没有观察到性别差异。与年龄较大的受试者相比，65 岁以下受试者的 SIR 存在显着差异，且具有持续的超额风险。总体而言，口腔癌、咽癌、喉癌、结缔癌、皮肤非黑色素瘤、卵巢癌和肾癌的异时性癌症的 SIR 显着升高。对于每个癌症部位，进一步评估了发生 MP 的特定部位风险。识别强的位点特异性关联可能对临床医生在随访患者时有用。 (C) 2001 Elsevier Science Ltd. 保留所有权利。
Data collected from eleven Italian population-based cancer registries (overall population 7 200 000 inhabitants) were used to compute the incidence of second independent cancers (MP) in a cohort of cancer patients aged 15 years or more. Overall, 240 111 patients have been followed for 544 438 person-years during which 8766 second primary cancers were diagnosed leading to an observed to expected ratio (SIR) of MP of 1.08 (95% Confidence Interval (CI): 1.05-1.12). Restricting the analysis to metachronous cancers, there were 6974 second primary cancers diagnosed among 198 303 patients during 508,648 person-years with an SIR of 0.93 (95% CI: 0.90-0.96). According to the time since first cancer diagnosis, the SIR was significantly higher than expected during the first 2 months, then the overall risk was slightly lower than 1 up to 10 years after diagnosis. No differences were observed according to gender. The SIR significantly differed among the age groups with consistent excess risks in subjects younger than 65 years in comparison with older ones. Overall, significantly elevated SIR for metachronous cancers were evidenced for oral cavity and pharynx, larynx, connective, skin non-melanoma, ovary and kidney cancers. For each cancer site, the site-specific risk of further MP has been evaluated. The identification of strong site-specific associations may be useful for clinicians when following-up patients. (C) 2001 Elsevier Science Ltd. All rights reserved.