Role of radiotherapy in the primary management of mucosal melanoma of the head and neck.
Role of radiotherapy in the primary management of mucosal melanoma of the head and neck.
复制标题
放射治疗在头颈部粘膜黑色素瘤初级治疗中的作用。
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
L. Peters
中科院分区：
文献类型：
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作者：
A. Trotti;L. Peters
从历史上看，放射治疗在粘膜黑色素瘤的治疗中发挥了非常小的作用，主要是因为该疾病具有放射抗性。最近关于皮肤黑色素瘤的放射生物学和临床反应的观察促使研究人员重新评估放疗在粘膜黑色素瘤中的作用。在过去十年中发表的一系列报告中，单独使用放射治疗的完全缓解率为50-75%，其中一半至三分之二的完全缓解者获得了持久的长期控制。这些数据，结合单独手术后局部失败的高发生率，表明放射治疗在综合治疗方法中作为手术辅助手段具有有用的作用，并且在不可切除疾病的初级管理中具有价值。根据现有数据的管理准则。
Historically, radiotherapy has played a very small role in the management of mucosal melanoma, largely because the disease has been characterized as radioresistant. Recent observations regarding the radiobiology and clinical response of cutaneous melanoma have prompted investigators to reevaluate the role of radiotherapy in mucosal melanoma. A series of reports published during the last decade using radiotherapy alone have documented complete response rates of 50-75% with durable long-term control in half to two thirds of the complete responders. These data, taken in conjunction with the high rate of local failure after surgery alone, suggest that radiotherapy would have a useful role as a surgical adjuvant in a combined modality approach, as well as being of value in the primary management of unresectable disease. Guidelines for management based on the available data are presented.
区域放射治疗作为头颈部恶性黑色素瘤的辅助治疗。
DOI：
10.1001/archotol.1990.01870020045012
发表时间：
1990
期刊：
Archives of otolaryngology--head & neck surgery
影响因子：
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作者：
Ang,KK;Byers,RM;Peters,LJ;Maor,MH;Wendt,CD;Morrison,WH;Hussey,DH;Goepfert,H
通讯作者：
Goepfert,H