MYOCARDIAL INFARCT SIZE AND VENTRICULAR-FUNCTION IN RATS
MYOCARDIAL INFARCT SIZE AND VENTRICULAR-FUNCTION IN RATS
复制标题
DOI：
10.1161/01.res.44.4.503
复制
发表时间：
1979-01-01
影响因子：
20.1
通讯作者：
BRAUNWALD, E
中科院分区：
文献类型：
--
作者：
PFEFFER, MA;PFEFFER, JM;BRAUNWALD, E
为了明确梗死面积与心室功能之间的关系，我们对大鼠左冠状动脉闭塞21天后的血流动力学进行了研究。在乙醚麻醉下，通过测量基线血流动力学和应激性能来评估心室性能，这些性能由静脉注射容量负荷时获得的心输出量峰值和脑卒中量以及升主动脉闭塞时左心室发展压力峰值确定。通过左心室4张组织学切片心内膜周长的平面测量来确定梗死面积。与假手术、非梗死大鼠相比，小心肌梗死大鼠（4-30%）在基线血流动力学或泵送和产生压力能力的峰值指数方面没有明显的损害。中度（31-46%）梗死的大鼠基线血流动力学正常，但峰值血流指数降低并出现压力。脑梗死的大鼠有充血性心力衰竭，充盈压力升高，心输出量减少，对负荷前和负荷后应激的反应能力最低。观察梗死后心室功能的整个频谱，从无可检测的损害到充血性衰竭。在组织学愈合的心肌梗死模型中，左心室功能损害与心肌损失直接相关。
To define the relationship between infarct size and ventricular performance, hemodynamics in rats 21 days after left coronary artery occlusion were studied. Ventricular performance was assessed under ether anesthesia by measurements of baseline hemodynamics and stressed performance as determined by peak cardiac output and stroke volume obtained during i.v. volume loading and by peak left ventricular developed pressure during occlusion of the ascending aorta. Infarct size was determined by planimetry of the endocardial circumference of each of 4 histological slices of the left ventricle. Rats with small (4-30%) myocardial infarctions had no discernible impairment in baseline hemodynamics or peak indices of pumping and pressure-generating ability when compared to sham-operated, noninfarcted rats. Rats with moderate (31-46%) infarctions had normal baseline hemodynamics but reduced peak flow indices and developed pressure. Rats with infarctions > 46% had congestive heart failure, with elevated filling pressures, reduced cardiac output and a minimal capacity to respond to pre- and afterload stresses. The entire spectrum of post-infarction ventricular function was observed, from no detectable impairment to congestive failure. In this model of histologically healed myocardial infarction, impairment of left ventricular function was directly related to loss of myocardium.