Novel Combined Lidocaine/Povidone Iodine Delivery System for Preintravitreal Injection.
Novel Combined Lidocaine/Povidone Iodine Delivery System for Preintravitreal Injection.
复制标题
用于玻璃体内注射的新型利多卡因/聚维酮碘联合输送系统。
DOI：
10.1089/jop.2021.0095
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
DiLeo,MorganV
中科院分区：
文献类型：
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作者：
Ziaei,Parissa;Resnick,JaydeL;Stella,Nicholas;DiLeo,MorganV
目的：玻璃体内注射已成为一种流行的治疗各种视网膜疾病，并显着增加，在过去的几年里。在传统的玻璃体内注射前，对于每天进行大量注射的从业者来说，准备步骤是耗时的。此外，利多卡因凝胶（L-凝胶）显示了潜在的吸收屏障上的聚维酮碘（PI）的抗菌作用的方法：在这项研究中，我们描述了L/PI凝胶系统作为一种替代方法来解决这些问题，为传统的注射前给药。利多卡因和PI装载在一个温敏凝胶滴注作为一种液体的下穹窿，过渡到一个稳定的，固体凝胶depot.Results和结论：凝胶表现出减少结膜触觉敏感性和足够的细菌杀死与一个单一的步骤，这表明显着减少所需的时间和药物抑制由于顺序给药的可能性较小。
Purpose:Intravitreal injection has become a popular treatment for various retina disorders and dramatically increased over the past few years. In traditional preintravitreal injection, the preparation steps are time consuming for practitioners who perform a significant number of injections per day. Besides, lidocaine gel (L-Gel) shows a potential absorption barrier on the antibacterial effect of povidone iodine (PI).Methods:In this study, we describe a L/PI gel system as an alternative approach to address these issues for traditional preinjection drug administration. Lidocaine and PI are loaded in a thermoresponsive gel instilled as a liquid to the lower fornix that transitions to a stable, solid gel depot.Results and Conclusion:The gel demonstrated decrease in conjunctival touch sensitivity and sufficient bacteria killing with a single step, suggesting a significant decrease in the time required and less potential for drug inhibition due to sequential administration.