Prevalence, incidence and risk factors of strabismus in a Chinese population-based cohort of preschool children: the Nanjing Eye Study
Prevalence, incidence and risk factors of strabismus in a Chinese population-based cohort of preschool children: the Nanjing Eye Study
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中国学龄前儿童人群斜视的患病率、发病率和危险因素：南京眼科研究。
DOI：
10.1136/bjophthalmol-2020-316807
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发表时间：
2021-09-01
影响因子：
4.1
通讯作者：
Liu, Hu
中科院分区：
文献类型：
--
作者：
Chen, Danni;Li, Rui;Liu, Hu
目的：评估中国学龄前儿童斜视的患病率、发病率及其相关危险因素。
方法：2011年9月至2012年8月在南京雨花台区出生的儿童自2015年起每年受邀参加南京眼研究，进行全面的眼部检查。本文所呈现的数据来自2015年至2017年，此时这些儿童年龄从3岁增长到5岁。眼部检查包括视力、眼前节、眼后节、屈光以及眼位和眼球运动。采用单变量和多变量逻辑回归模型对现患斜视和新发斜视的危险因素进行评估。
结果：2015年，在2300名符合条件的学龄前儿童中，共有2018名儿童（应答率为87.7%）在3岁时完成了基线眼部检查。在2018名参与者中，50人患有斜视（患病率为2.48%）。在多变量分析中，现患斜视与父母斜视病史独立相关（比值比 = 11.60，p<...（此处原文不完整）
Aims To evaluate the prevalence, incidence and their related risk factors of strabismus among preschool children in China. Methods Children born between September 2011 and August 2012 in Yuhuatai District of Nanjing were invited to participate in the Nanjing Eye Study for a comprehensive eye examination annually since 2015. The data presented in this paper were obtained from 2015 to 2017, when these children grew from the age of 3 to 5 years. Eye examinations included visual acuity, anterior segment, posterior segment, refraction, and ocular alignment and motility. Risk factors were evaluated using univariable and multivariable logistic regression models for prevalent and incident strabismus. Results In 2015, a total of 2018 children (87.7% response rate) of 2300 eligible preschoolers completed the baseline eye examination when they were 3 years old. Among the 2018 participants, 50 had strabismus (prevalence rate, 2.48%). In multivariable analysis, prevalent strabismus was independently associated with parental strabismus history (OR=11.60, p<0.001), hyperopia (OR=6.22, p<0.001), prematurity (OR=3.07, p=0.01) and astigmatism (OR=2.15, p=0.04). Among 1766 children followed up for 2 years, 63 developed strabismus (annual incidence rate, 1.78%), of whom 57 had exotropia and 6 had esotropia. In multivariable analysis, incident strabismus was significantly associated with parental strabismus history (OR=5.55, p=0.04) and prematurity (OR=3.77, p<0.001). Conclusions In this population-based cohort study, we found a higher incidence of strabismus and a higher exotropia:esotropia ratio than previous studies in preschool children. Parental strabismus history and prematurity were associated with a higher risk for both prevalent and incident strabismus.