Central versus peripheral actions of Leu-enkephalin on acquisition of a one-way active avoidance response in rats

Central versus peripheral actions of Leu-enkephalin on acquisition of a one-way active avoidance response in rats
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亮氨酸脑啡肽对大鼠单向主动回避反应的中枢与外周作用的影响

DOI:
10.1016/0006-8993(85)91496-9
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发表时间:
1985
期刊:
影响因子:
2.9
通讯作者:
R. Dana
R. Dana
中科院分区:
医学3区
文献类型:
--
作者:
J. L. Martinez;P. Conner;R. Dana

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A comparison was carried out of the effectiveness of intracerebroventricular or intraperitoneal administration of Leu-enkephalin to affect acquisition of a one-way active avoidance response, locomotor activity or shock sensitivity. Leu-enkephalin impaired acquisition of the avoidance response only when administered peripherally. In contrast, either central or peripheral administration of Leu-enkephalin increased locomotor activity in the open field, and Leu-enkephalin also produced analgesia when administered directly into the brain. The pattern of results suggests that Leu-enkephalin acts at a peripheral site to influence avoidance conditioning.
DOI: --
发表时间: 1982
期刊: The Journal of pharmacology and experimental therapeutics
影响因子: --
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期刊: Advances in biochemical psychopharmacology
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发表时间: 1980
期刊: Nature
影响因子: 64.8
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