Targeted delivery of magnetic aerosol droplets to the lung
Targeted delivery of magnetic aerosol droplets to the lung
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DOI：
10.1038/nnano.2007.217
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发表时间：
2007-08-01
影响因子：
38.3
通讯作者：
Rudolph, Carsten
中科院分区：
文献类型：
--
作者：
Dames, Petra;Gleich, Bernhard;Rudolph, Carsten
吸入医用气雾剂被广泛用于治疗肺部疾病，如哮喘、慢性阻塞性肺病（1）、囊性纤维化（2）、呼吸道感染（3）以及最近的肺癌（4）。向受影响的肺组织的靶向气雾剂递送可以提高治疗效率并使不希望的副作用最小化。尽管在优化气雾剂输送到肺部方面取得了巨大进展，但迄今为止尚未充分实现气雾剂输送到气道或肺外周以外的特定肺部区域（5，6）。在这里，我们通过计算机辅助模拟从理论上表明，并首次在小鼠中进行实验，可以用包含超顺磁性氧化铁纳米颗粒（所谓的纳米磁溶胶）的气溶胶液滴与靶向磁梯度场相结合来实现向肺部的靶向气溶胶递送。我们认为，纳米磁溶胶可能是有用的治疗局部肺部疾病，针对病灶的细菌感染或肿瘤结节。
The inhalation of medical aerosols is widely used for the treatment of lung disorders such as asthma, chronic obstructive pulmonary disease(1), cystic fibrosis(2), respiratory infection(3) and, more recently, lung cancer(4). Targeted aerosol delivery to the affected lung tissue may improve therapeutic efficiency and minimize unwanted side effects. Despite enormous progress in optimizing aerosol delivery to the lung, targeted aerosol delivery to specific lung regions other than the airways or the lung periphery has not been adequately achieved to date(5,6). Here, we show theoretically by computer-aided simulation, and for the first time experimentally in mice, that targeted aerosol delivery to the lung can be achieved with aerosol droplets comprising superparamagnetic iron oxide nanoparticles-so-called nanomagnetosols-in combination with a target-directed magnetic gradient field. We suggest that nanomagnetosols may be useful for treating localized lung disease, by targeting foci of bacterial infection or tumour nodules.