Effect of smoking on physical function in older adults: a Mendelian randomisation analysis
Effect of smoking on physical function in older adults: a Mendelian randomisation analysis
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DOI：
10.1136/jech-2021-217572
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发表时间：
2022-02-10
影响因子：
6.3
通讯作者：
Gaggero, Alessio
中科院分区：
文献类型：
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作者：
Gaggero, Alessio
背景众所周知，吸烟有害健康。它大大增加了患各种癌症、心血管和呼吸系统疾病的风险，仍然是英国发病率和死亡率的主要可预防原因。该文章检验了吸烟行为（吸烟或不吸烟）与身体功能相关的假设，并使用吸烟行为的遗传易感性作为工具变量评估了推断的因果关系。方法和结果数据来自英国老龄化纵向研究，波1-9（平均年龄65.8岁）。通过身体活动度和日常生活活动指数评估身体功能。吸烟行为的多基因评分被用作孟德尔随机化框架中的工具变量。工具变量估计被用来检查因果关系。在英国老年人（n=29 139），受损的身体功能显着高于（当前）吸烟者与非吸烟者相比。相对于非吸烟者，吸烟者报告的身体活动指数（β =5.553; 95% CI 1.029至10.077）和日常生活活动指数（β =1.908; 95% CI 0.196至3.619）受损水平更高。结论这项研究表明，吸烟行为是一个潜在的因果危险因素，在英国人口老龄化过程中的身体功能。因此，戒烟的好处可以扩展到身体功能。
Background Smoking is widely known to be damaging to health. It greatly increases the risk of various cancers, cardiovascular and respiratory diseases, and remains the leading preventable cause of morbidity and mortality in the UK. The article tested the hypothesis that smoking behaviour (either smoking or non-smoking) is associated with physical function, and assessed inferred causality using genetic predisposition to smoking behaviour as an instrumental variable. Methods and findings Data were drawn from the English Longitudinal Study of Ageing, waves 1-9 (mean age 65.8 years). Physical function was assessed by means of the body mobility and the activity of daily living indices. Polygenic scores for smoking behaviour were used as instrumental variables in a Mendelian randomisation framework. Instrumental variable estimators were used to examine causal effects. Among UK older adults (n=29 139), impaired physical function was significantly higher in (current) smokers compared with non-smokers. Relatively to non-smokers, smokers reported a higher level of impairment both in the body mobility index (beta=5.553; 95% CI 1.029 to 10.077) and in the activities of daily living index (beta=1.908; 95% CI 0.196 to 3.619). Conclusions This study demonstrates smoking behaviour to be a potential causal risk factor for physical function during ageing in the UK population. Accordingly, the benefits of smoking cessations may extend to physical function.