Antileishmanial Germacranolides from Calea zacatechichi.
Antileishmanial Germacranolides from Calea zacatechichi.
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来自 Calea zacatechichi 的抗利什曼尼热尔马诺内酯。
DOI：
10.1055/s-0030-1250584
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发表时间：
2011
期刊：
影响因子：
2.7
通讯作者：
Zjawiony,JordanK
中科院分区：
文献类型：
--
作者：
Wu,Hankui;Fronczek,FrankR;BurandtJr,CharlesL;Zjawiony,JordanK
新疆吊兰叶和茎的植物化学研究。（菊科）分离得到一系列具有显著抗利什曼原虫活性的6个大根霉内酯（1-6）。通过NMR和MS确定了一个新化合物的结构，命名为calealactone D（1），并通过X射线晶体学确定了其绝对构型。此外，金合欢内酯E（5）被发现为一种新的天然化合物，金合欢内酯C（2）的绝对构型也通过X射线晶体学确定。所有化合物在抗微生物和抗原虫测定中进行生物学评价。
Phytochemical study of the leaves and stems of Calea zacatechichi Schl.(Asteraceae) led to the isolation of a series of six germacranolides (1–6) with significant antileishmanial activity. The structure of a new compound named by us as calealactone D (1) was determined by NMR and MS, and its absolute configuration by X‐ray crystallography. In addition, calealactone E (5) was discovered as a new naturally occurring compound, and the absolute configuration of calealactone C (2) was also determined by X‐ray crystallography. All compounds were biologically evaluated in antimicrobial and antiprotozoal assays.