Gold glyconanoparticles as new tools in antiadhesive therapy
Gold glyconanoparticles as new tools in antiadhesive therapy
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DOI：
10.1002/cbic.200300726
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发表时间：
2004-03-05
期刊：
影响因子：
3.2
通讯作者：
Penadés, S
中科院分区：
文献类型：
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作者：
Rojo, J;Díaz, V;Penadés, S
金糖纳米颗粒（GNPs）是一种新的多价工具，可以在细胞表面模拟鞘糖脂。GNPs在生理条件下高度可溶，抗酶降解稳定且无毒。因此，GNPs为生物应用开辟了一个新的有前途的多价平台。最近有研究表明，特定的肿瘤相关碳水化合物抗原（糖鞘脂和糖蛋白）参与了肿瘤扩散的初始步骤，我们选择了一个小鼠黑色素瘤模型来测试糖聚糖颗粒作为实验性肺转移的可能抑制剂。碳水化合物-碳水化合物相互作用被认为是这一过程的第一个识别步骤。提出乳糖的糖聚糖颗粒（乳糖- gnps）已经成功地用于显著减少实验转移的进展。这一结果首次明确了乳酸- gnps的生物学效应，证明了这种糖纳米技术在生物过程中的潜在应用。
Gold glyconanoparticles (GNPs) have been prepared as new multivalent tools that mimic glycosphingolipids on the cell surface. GNPs are highly soluble under physiologicol conditions, stable against enzymatic degradation and nontoxic. Thereby GNPs open up a novel promising multivalent platform for biological applications. It has recently been demonstrated that specific tumor-associated carbohydrate antigens (glycosphingolipids and glycoproteins) are involved in the initial step of tumor spreading, A mouse melanoma model was selected to test glyconanoparticles as possible inhibitors of experimental lung metastasis. A carbohydrate-carbohydrate interaction is proposed as the first recognition step for this process. Glyconanoparticles presenting lactose (lacto-GNPs) hove been used successfully to significantly reduce the progression of experimental metastasis. This result shows for the first time a clear biological effect of lacto-GNPs, demonstrating the potential application of this glyconanotechnology in biological processes.