Expression of Tumor Necrosis Factor Receptors on Granulocytes in Patients with Myeloperoxidase Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis
Expression of Tumor Necrosis Factor Receptors on Granulocytes in Patients with Myeloperoxidase Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis
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DOI：
10.1159/000235242
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发表时间：
2009-01-01
影响因子：
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通讯作者：
Sugiyama, Satoshi
中科院分区：
文献类型：
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作者：
Hasegawa, Midori;Nishii, Chikako;Sugiyama, Satoshi
背景/目标：为了阐明肿瘤坏死因子（TNF）受体在髓过氧化物酶（MPO）-抗中性粒细胞胞浆抗体（ANCA）相关性血管炎患者中的临床意义，我们评估了TNF受体1（TNFR 1）和TNF受体2（TNFR 2）的细胞表面表达。患者和方法：本研究纳入了43例MPO-ANCA相关性血管炎患者、16例慢性肾衰竭患者、10例脓毒症患者、15例系统性红斑狼疮患者和18例健康对照，并评估了粒细胞表面TNFR 1、TNFR 2、CD 63和CD 64的表达水平。在21例MPO-ANCA相关性血管炎患者中，还测量了血清中可溶性TNFR 1（sTNFR 1）、可溶性TNFR 2（sTNFR 2）和TNF-α。结果如下：MPO-ANCA相关性血管炎患者粒细胞表面TNFR 1和TNFR 2的表达水平显著高于健康对照组，并与伯明翰血管炎活动评分（BVAS）呈正相关。血清中sTNFR 1、sTNFR 2和TNF-α水平在MPO-ANCA相关性血管炎患者中也显著高于健康对照组。血清sTNFR 1和sTNFR 2水平与血清肌酐相关，而粒细胞表面TNFR 1和TNFR 2的表达不相关。BVAS与CD 63或CD 64之间无显著相关性。结论：粒细胞表面TNFR 1和TNFR 2的表达水平在MPO-ANCA相关性血管炎患者中上调，反映了疾病的活动性。版权所有（C）2009 S. Karger AG，巴塞尔
Background/Aims: To clarify the clinical significance of tumor necrosis factor (TNF) receptors in patients with myeloperoxidase (MPO)-anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis, we evaluated the cell surface expression of TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Patients and Methods: 43 patients with MPO-ANCA-associated vasculitis, 16 patients with chronic renal failure, 10 patients with sepsis, 15 patients with systemic lupus erythematosus, and 18 healthy controls were enrolled in this study, and the surface expression levels of TNFR1, TNFR2, CD63, and CD64 on granulocytes were assessed. In 21 patients with MPO-ANCA-associated vasculitis, soluble TNFR1 (sTNFR1), soluble TNFR2 (sTNFR2), and TNF-alpha in the serum were also measured. Results: The surface expression levels of TNFR1 and TNFR2 on granulocytes were significantly higher in patients with MPO-ANCA-associated vasculitis than in the healthy controls, and positively correlated with the Birmingham Vasculitis Activity Score (BVAS). The levels of sTNFR1, sTNFR2, and TNF-alpha in the serum were also significantly higher in patients with MPO-ANCA-associated vasculitis than in the healthy controls. Serum levels of sTNFR1 and sTNFR2 correlated with serum creatinine, while the surface expression of TNFR1 and TNFR2 on the granulocytes did not. There was no significant correlation between the BVAS and CD63 or BVAS and CD64. Conclusion: The surface expression levels of TNFR1 and TNFR2 on granulocytes were upregulated in patients with MPO-ANCA-associated vasculitis and reflected disease activity. Copyright (C) 2009 S. Karger AG, Basel