Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools.
Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools.
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DOI：
10.1155/2018/3719703
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发表时间：
2018
影响因子：
--
通讯作者：
Szlęk J
中科院分区：
文献类型：
--
作者：
Polak S;Wiśniowska B;Mendyk A;Pacławski A;Szlęk J
人体心脏电生理是一种复杂的生物学现象，通过测量心电信号来间接评价。进一步分析ECG迹线以导出可解释的替代物，包括QT间期、QRS波群、PR间期和T波形态。QT间期及其变化是药物触发心律失常最常用的替代物，但已知QT间期本身由其他非药物相关的生理和病理参数决定。在当前的研究中，我们使用计算智能算法来分析各种模拟生理参数与QT间期之间的相关性。以特非那定与8种酶抑制剂同时给药为例。使用遗传编程技术开发的方程导致关于QT延长的变化的一般推理。对于QT间期的微小变化，药物相关的IKr和伊卡电流抑制电位具有主要影响。生理参数如体表面积、钾、钠和钙离子浓度可忽略不计。生理变量的影响随着QT的更显著变化而逐渐增加。由于显著的QT间期延长与药物触发的心律失常风险相关，因此分析影响ECG的生理参数的作用似乎是可取的。
Human heart electrophysiology is complex biological phenomenon, which is indirectly assessed by the measured ECG signal. ECG trace is further analyzed to derive interpretable surrogates including QT interval, QRS complex, PR interval, and T wave morphology. QT interval and its modification are the most commonly used surrogates of the drug triggered arrhythmia, but it is known that the QT interval itself is determined by other nondrug related parameters, physiological and pathological. In the current study, we used the computational intelligence algorithms to analyze correlations between various simulated physiological parameters and QT interval. Terfenadine given concomitantly with 8 enzymatic inhibitors was used as an example. The equation developed with the use of genetic programming technique leads to general reasoning about the changes in the prolonged QT. For small changes of the QT interval, the drug-related IKr and ICa currents inhibition potentials have major impact. The physiological parameters such as body surface area, potassium, sodium, and calcium ions concentrations are negligible. The influence of the physiological variables increases gradually with the more pronounced changes in QT. As the significant QT prolongation is associated with the drugs triggered arrhythmia risk, analysis of the role of physiological parameters influencing ECG seems to be advisable.
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影响因子：
8
作者：
Szlęk J;Pacławski A;Lau R;Jachowicz R;Mendyk A
通讯作者：
Mendyk A
影响因子：
2.9
作者：
Martin, DE;Zussman, BD;Jorkasky, DK
通讯作者：
Jorkasky, DK
影响因子：
4.5
作者：
FRIEDMAN, JH
通讯作者：
FRIEDMAN, JH
DOI：
10.1007/bf03258467
发表时间：
1994-03-01
期刊：
DRUG INVESTIGATION
影响因子：
--
作者：
HONIG, PK;WORTHAM, DC;CANTILENA, LR
通讯作者：
CANTILENA, LR
影响因子：
6.1
作者：
Szlek, Jakub;Paclawski, Adam;Mendyk, Aleksander
通讯作者：
Mendyk, Aleksander