Serum TNFRII: A promising biomarker for predicting the risk of subcentimetre lung adenocarcinoma
Serum TNFRII: A promising biomarker for predicting the risk of subcentimetre lung adenocarcinoma
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血清 TNFRII：预测亚厘米肺腺癌风险的有前途的生物标志物
DOI：
10.1111/jcmm.15071
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发表时间：
2020
影响因子：
5.3
通讯作者：
Han Baohui
中科院分区：
文献类型：
--
作者：
Hu Minjuan;Zhang Yanwei;Sun Beibei;Lou Yuqing;Zhang Xueyan;Wang Huimin;Huang Chengya;Zhang Wei;Chu Tianqing;Han Baohui
肺腺癌的早期诊断需要有效的风险预测。据报道，TNFRII与肿瘤发生有关，但在肺癌中仍不清楚。本研究旨在探讨sTNFRII（血清TNFRII）水平与直径小于1厘米的肺腺癌风险之间的关系。通过多重基于微珠的Luminex检测分析了71对亚厘米级肺腺癌患者和健康对照，发现亚厘米级肺腺癌患者的sTNFRII表达显著低于健康对照（P < .001），这通过ONCOMINE数据库分析进一步验证。sTNFRII水平升高可使亚厘米级肺腺癌的风险降低89%（P <0.001）。BLC水平较高的患者发生亚厘米级腺癌的风险高2.70倍（P <0.01）。此外，较高的BLC/TNFRII比值与亚厘米级腺癌的风险高出35倍有关。TNFRII显示出良好的特异性、敏感性和准确性（分别为0.72、0.75和0.73），AUC为0.73（P <0.001）。总之，本研究评估了sTNFRII作为预测亚厘米级肺腺癌风险的潜在生物标志物的价值，并为进一步使用TNFRII作为亚厘米级肺腺癌诊断的辅助标志物提供了证据。
Early diagnosis of lung adenocarcinoma requires effective risk predictors. TNFRII was reported to be related to tumorigenesis, but remained unclear in lung cancer. This research set out to investigate the relationship between the sTNFRII (serum TNFRII) level and the risk of lung adenocarcinoma less than 1 cm in diameter. Seventy‐one pairs of subcentimetre lung adenocarcinoma patients and healthy controls were analysed through multiplex bead‐based Luminex assay and found a significantly lower expression of sTNFRII in patients with subcentimetre lung adenocarcinoma than that in the healthy controls (P < .001), which was further verified through ONCOMINE database analysis. Increased levels of sTNFRII reduced the risk of subcentimetre lung adenocarcinoma by 89% (P < .001). Patients with a higher level of BLC had a 2.70‐fold (P < .01) higher risk of subcentimetre adenocarcinoma. Furthermore, a higher BLC/TNFRII ratio was related to a 35‐fold higher risk of subcentimetre adenocarcinoma. TNFRII showed good specificity, sensitivity and accuracy (0.72, 0.75 and 0.73, respectively), with an AUC of 0.73 (P < .001). In conclusion, the present study assessed the value of sTNFRII as a potential biomarker to predict the risk of subcentimetre lung adenocarcinoma and provided evidence for the further use of TNFRII as an auxiliary marker in the diagnosis of subcentimetre lung adenocarcinoma.