Posttraumatic stress disorder symptoms, salivary cortisol, medication adherence, and CD4 levels in HIV-positive individuals
Posttraumatic stress disorder symptoms, salivary cortisol, medication adherence, and CD4 levels in HIV-positive individuals
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DOI：
10.1080/09540120410001641084
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发表时间：
2004-02-01
影响因子：
1.7
通讯作者：
Figler, JL
中科院分区：
文献类型：
--
作者：
Delahanty, DL;Bogart, LM;Figler, JL
先前的研究报告了创伤后应激障碍（PTSD）在诊断为危及生命的疾病后的发病率从5%到42%不等。然而，很少有研究探讨创伤后应激障碍症状对疾病标志物或药物治疗依从性的影响。本研究代表了对110名非洲裔美国人和白人HIV感染者自我报告的PTSD症状之间的关系的初步检查，这些症状源于HIV诊断、CD 4细胞计数、唾液皮质醇水平和坚持高效抗逆转录病毒治疗（HAART）。结果显示，PTSD和疾病进展之间的关系是多方面的：PTSD症状与HAART治疗依从性较差有关，但也与早晨唾液皮质醇水平较低和CD 4细胞计数较高有关。
Previous research has reported rates of posttraumatic stress disorder ( PTSD) following diagnosis with a life- threatening disease ranging from 5 to 42%. However, few studies have examined the impact of PTSD symptoms on disease markers or adherence to medical regimens. The present study represents an initial examination of the relationships among self- reported PTSD symptoms stemming from diagnosis with HIV, CD4 cell counts, salivary cortisol levels and adherence to highly active antiretroviral therapy ( HAART) in 110 African- American and Caucasian individuals with HIV. Results revealed that the relationship between PTSD and disease progression is multifaceted: PTSD symptoms were related to worse adherence to HAART therapy, but were also associated with lower morning salivary cortisol levels and higher CD4 cell counts.