Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs
Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs
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DOI：
10.1038/modpathol.3800685
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发表时间：
2007-02-01
期刊：
影响因子：
7.5
通讯作者：
Fukushima, Noriyoshi
中科院分区：
文献类型：
--
作者：
Hruban, Ralph H.;Fukushima, Noriyoshi
胰腺癌是美国癌症死亡的第四大原因。大多数胰腺癌是浸润性导管腺癌。仔细应用明确的形态学标准可用于区分浸润性导管腺癌和反应性腺体。虽然大多数胰腺癌是导管腺癌，但已描述了许多组织学定义的变体。这些是重要的认识，因为他们有不同的临床病理特征。胰腺上皮内瘤变（PanIN）被认为是浸润性导管腺癌的前驱病变，PanIN病变可以模拟浸润性癌症。
Pancreatic cancer is the fourth leading cause of cancer death in the US. Most pancreatic cancers are infiltrating ductal adenocarcinomas. The careful application of well-defined morphologic criteria can be used to differentiate between infiltrating ductal adenocarcinoma and reactive glands. While most pancreatic cancers are ductal adenocarcinomas, a number of histologically defined variants have been described. These are important to recognize because they have distinct clinical pathologic features. Pancreatic intraepithelial neoplasia (PanIN) is the presumed precursor lesion to infiltrating ductal adenocarcinoma, and PanIN lesions can mimic infiltrating cancer.