Analytical validation in erythrocyte immunohematology
Analytical validation in erythrocyte immunohematology
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DOI：
10.1016/s1246-7820(00)80017-8
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发表时间：
2000-06-01
影响因子：
1.7
通讯作者：
Lejealle, A
中科院分区：
文献类型：
--
作者：
Mannessier, L;Roubinet, F;Lejealle, A
在输血或胎儿-母体接触中，由于抗红细胞抗体（规则或不规则）引起的不相容性溶血仍然是受者中最常见和最严重的免疫风险。为了防止这种风险，必须采取一些措施，例如实现免疫血液学分析，由于其严重的临床后果，其方法学实践已被立法。有几个因素在分析及其结果的可靠性中发挥作用：试剂的选择及其在所用常规技术中的验证;接收的验证;二次制备中涉及的控制（例如，血细胞试剂）;和每日内部对照。所有这一切都需要选择合适的控制措施和管理可能的异常情况。(C)2000年，Elsevier SAS科学与医学版。
In a transfusional or foeto-maternal conte,rt, hemolysis by incompatibility due to anti-erythrocyte antibodies (regular or irregular) remains the most frequent and most serious immunological risk in the receiver. In order to prevent this risk, a number of actions must be taken, such as the realization of the immunohematologic analyses for which the methodological practices have been legislated because of their serious clinical consequences. Several elements play a role in the reliability of the analyses and their results: the selection of the reagents and their validation in the routine technique used; the validation of reception; the controls involved in secondary preparations (e.g., blood cells reagent); and the daily internal controls. All this requires the choice of adapted controls and the management of possible anomalies. (C) 2000 Editions scientifiques et medicales Elsevier SAS.