Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation.
Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation.
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DOI：
10.1084/jem.194.7.991
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发表时间：
2001-10-01
影响因子：
15.3
通讯作者：
Parreira, L
中科院分区：
文献类型：
--
作者：
Jaleco, A C;Neves, H;Hooijberg, E;Gameiro, P;Clode, N;Haury, M;Henrique, D;Parreira, L
Notch signaling is known to differentially affect the development of lymphoid B and T cell lineages, but it remains unclear whether such effects are specifically dependent on distinct Notch ligands. Using a cell coculture assay we observed that the Notch ligand Delta-1 completely inhibits the differentiation of human hematopoietic progenitors into the B cell lineage while promoting the emergence of cells with a phenotype of T cell/natural killer (NK) precursors. In contrast, Jagged-1 did not disturb either B or T cell/NK development. Furthermore, cells cultured in the presence of either Delta-1 or Jagged-1 can acquire a phenotype of NK cells, and Delta-1, but not Jagged-1, permits the emergence of a de novo cell population coexpressing CD4 and CD8. Our results thus indicate that distinct Notch ligands can mediate differential effects of Notch signaling and provide a useful system to further address cell-fate decision processes in lymphopoiesis.
