Adaptive Laboratory Evolution: This tool for studying molecular mechanisms and evolutionary dynamics follows bacteria as they adapt to environmental stress
Adaptive Laboratory Evolution: This tool for studying molecular mechanisms and evolutionary dynamics follows bacteria as they adapt to environmental stress
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DOI：
10.1128/microbe.6.69.1
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发表时间：
2011-02
期刊：
影响因子：
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通讯作者：
B. Palsson
中科院分区：
文献类型：
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作者：
B. Palsson
我们现在可以在实验室实验中观察进化，定义其动力学，并确定新表型背后的遗传变化。然而，在这种实验中发生的事情可能不能直接适用于自然栖息地的进化，除非特定的栖息地可以在实验室中精确地复制。然而，适应性实验室进化（ALE）的实验正在产生微生物学的基本见解。
We now can observe evolution in laboratory experiments, define its dynamics, and determine the genetic changes underlying new phenotypes. What happens in such experiments may not be directly applicable to evolution in natural habitats, however, unless particular habitats can be accurately reproduced in the laboratory. Nevertheless, experiments in adaptive laboratory evolution (ALE) are yielding fundamental insights in microbiology.