Racial difference in lung function in African-American and White children: Effect of anthropometric, socioeconomic, nutritional, and environmental factors
Racial difference in lung function in African-American and White children: Effect of anthropometric, socioeconomic, nutritional, and environmental factors
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DOI：
10.1093/aje/kwh297
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发表时间：
2004-11-01
影响因子：
5
通讯作者：
Wise, RA
中科院分区：
文献类型：
--
作者：
Harik-Khan, RI;Muller, DC;Wise, RA
非裔美国儿童的肺容量低于白人儿童。然而，人体测量、社会经济、营养和环境因素对这种差异的影响尚不清楚。作者从第三次全国健康和营养调查（1988-1994）的参与者中选择了 1,462 名 8-17 岁健康不吸烟儿童（623 名白人和 839 名非裔美国人）。非裔美国儿童更高、更重，但肺功能较低。非裔美国人较贫穷，抗氧化剂维生素 A 和 C 以及 α-胡萝卜素的水平较低。作者利用人体测量、社会经济、营养因素以及烟雾暴露的数据进行了回归分析。坐高的调整解释了 42-53% 的种族差异。社会经济因素和抗氧化维生素水平另外占 7-10%。总体而言，作者只能解释 50-63% 的种族差异。在家中接触烟草与女孩 1 秒用力呼气量的相关性较弱，仅占差异的 1%。在 8-12 岁儿童 (n = 752) 中，出生体重解释了 3-5% 的种族差异，而子宫内暴露于母亲吸烟没有显着影响。作者得出的结论是，在健康儿童中，肺功能种族差异的主要解释变量是身体习惯；社会经济、营养和环境混杂因素的影响较小。
African-American children have lower lung volumes than White children. However, the contributions of anthropometric, socioeconomic, nutritional, and environmental factors to this difference are unknown. From participants in the Third National Health and Nutrition Examination Survey (1988-1994), the authors selected 1,462 healthy nonsmoking children (623 White and 839 African-American) aged 8-17 years. The African-American children were taller and heavier but had lower lung function. African Americans were poorer and had lower levels of the antioxidant vitamins A and C and alpha-carotene. The authors performed regression analyses using data on anthropometric, socioeconomic, and nutritional factors and smoke exposure. Adjustment for sitting height explained 42-53% of the racial difference. Socioeconomic factors and antioxidant vitamin levels accounted for an additional 7-10%. Overall, the authors could account for only 50-63% of the racial difference. Exposure to tobacco in the home was weakly associated with forced expiratory volume in 1 second in girls, accounting for 1% of the difference. In children aged 8-12 years (n = 752), birth weight explained 3-5% of the racial difference, whereas in-utero exposure to maternal smoking had no significant effect. The authors conclude that in healthy children, the major explanatory variable for the racial difference in lung function is body habitus; socioeconomic, nutritional, and environmental confounders play a smaller role.