Histoplasmosis mimicking primary lung cancer or pulmonary metastases.
Histoplasmosis mimicking primary lung cancer or pulmonary metastases.
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DOI：
10.1590/s1806-37132013000100009
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Severo LC
中科院分区：
文献类型：
--
作者：
Dall Bello AG;Severo CB;Guazzelli LS;Oliveira FM;Hochhegger B;Severo LC
目的：探讨疑似肺癌的组织胞浆菌病的主要临床及影像学特征。 这是一项回顾性描述性研究，基于对1977年至2011年期间在巴西波尔图阿莱格雷市波尔图阿雷格里慈善医院Santa Casa姐妹篇真菌学实验室诊断为组织胞浆菌病的294例患者的病历分析。组织胞浆菌病的诊断通过培养、组织病理学检查或免疫扩散试验（M或H沉淀带的鉴定）确定。在确定了具有肉眼病变以及与恶性肿瘤一致的放射学和CT表现的患者后，我们将患者分为两组：具有癌症病史并表现出类似转移的病变的患者（HC组）;以及没有这种病史但也表现出类似转移的病变的患者（NHC组）。 在诊断为组织胞浆菌病的294例患者中，15例出现类似原发性肿瘤或转移的病变（HC组和NHC组分别为9例和6例）。患者的年龄范围为13至67岁（中位数为44岁）。在15名患者中，14名（93%）在住院时出现肺部病变。 肿瘤性疾病的临床和放射学综合征并不局限于恶性肿瘤，因此在鉴别诊断中必须考虑肉芽肿性感染性疾病。
To describe the main clinical and radiological characteristics of patients with histoplasmosis mimicking lung cancer. This was a retrospective descriptive study based on the analysis of the medical records of the 294 patients diagnosed with histoplasmosis between 1977 and 2011 at the Mycology Laboratory of the Santa Casa Sisters of Mercy Hospital of Porto Alegre in the city of Porto Alegre, Brazil. The diagnosis of histoplasmosis was established by culture, histopathological examination, or immunodiffusion testing (identification of M or H precipitation bands). After identifying the patients with macroscopic lesions, as well as radiological and CT findings consistent with malignancy, we divided the patients into two groups: those with a history of cancer and presenting with lesions mimicking metastases (HC group); and those with no such history but also presenting with lesions mimicking metastases (NHC group). Of the 294 patients diagnosed with histoplasmosis, 15 had presented with lesions mimicking primary neoplasia or metastases (9 and 6 in the HC and NHC groups, respectively). The age of the patients ranged from 13 to 67 years (median, 44 years). Of the 15 patients, 14 (93%) presented with pulmonary lesions at the time of hospitalization. The clinical and radiological syndrome of neoplastic disease is not confined to malignancy, and granulomatous infectious diseases must therefore be considered in the differential diagnosis.
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DOI：
10.1590/s0037-86822011000100007
发表时间：
2011-02-01
影响因子：
2
作者：
Antonello, Vicente Sperb;Zaltron, Vanice Ferrazza;Severo, Luiz Carlos
通讯作者：
Severo, Luiz Carlos
影响因子：
3.3
作者：
LOH, FC;YEO, JF;KUMARASINGHE, G
通讯作者：
KUMARASINGHE, G
影响因子：
11.8
作者：
Wheat, J;Sarosi, G;Kauffman, C
通讯作者：
Kauffman, C
影响因子：
2.3
作者：
McGraw, EP;Kane, JM;Scherer, LR
通讯作者：
Scherer, LR
影响因子：
5.6
作者：
Mukhopadhyay, Sanjay;Katzenstein, Anna-Luise A.
通讯作者：
Katzenstein, Anna-Luise A.