Lipid Peroxidation and Antioxidant Status in Preeclampsia A Systematic Review
Lipid Peroxidation and Antioxidant Status in Preeclampsia A Systematic Review
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DOI：
10.1097/ogx.0b013e3181bea0ac
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发表时间：
2009-11-01
影响因子：
6.2
通讯作者：
Agarwal, Ashok
中科院分区：
文献类型：
--
作者：
Gupta, Sajal;Aziz, Nabil;Agarwal, Ashok
背景资料：先兆子痫的特征是脂质过氧化作用增加和抗氧化能力降低;然而，对于这些条件的程度还没有达成共识。目的：使用荟萃分析定量评估脂质过氧化和抗氧化状态与先兆子痫的关系。设计：系统回顾和荟萃分析。检索策略：通过使用BIOSIS进行广泛检索来识别研究（1986-2007年），EMBASE（1986-2007），Medline（1986-2007）和科克伦数据库。荟萃分析中使用了标准化平均差（SMD）和95%置信区间（CI），并检查了异质性的来源。主要结果：在纳入的研究中，与对照组相比，先兆子痫病例的血清丙二醛总体SMD增加1.21 nmol/mL（95% CI：0.76，1.66）。总体而言，病例组血清总硫代巴比妥酸反应物质SMD比对照组高1.62 nmol/mL（95% CI：0.27，2.96）。病例组血清维生素E的SMD总体估计值比对照组低1.12 nmol/mL（95%CI：-1.77，-0.48），维生素C SMD总体估计值为-0.53（95%CI：-1.03，-0.02），病例组显著低于对照组。红细胞超氧化物歧化酶的总SMD为-2.37（95%CI：-4.76，0.03），病例组与对照组相比略有显著性降低。结论：确诊的先兆子痫与氧化应激标志物（包括脂质过氧化产物）浓度升高和抗氧化剂浓度降低有关。在完成这项教育活动后，参与者应该能够更好地描述与先兆子痫相关的氧化应激标志物的模式，并解释与氧化应激和先兆子痫相关的现有文献。
Background: Preeclampsia is characterized by increased lipid peroxidation and diminished antioxidant capacity; however, there is no consensus as to the extent of these conditions.Objective: To assess the association of lipid peroxidation and antioxidant status with preeclampsia quantitatively using meta-analysis.Design: Systematic review and meta-analysis.Search Strategy: Studies were identified by performing an extensive search using BIOSIS (1986-2007), EMBASE (1986-2007), Medline (1986-2007), and the Cochrane database.Data Analysis: Standardized mean differences (SMD) with 95% confidence intervals (CI) were used in the meta-analysis and sources of heterogeneity were examined.Main Results: In the included studies, the overall SMD was a 1.21 nmol/mL increase in serum malondialdehyde in preeclampsia cases compared to controls (95% CI: 0.76, 1.66). Overall, total serum thiobarbituric acid-reactive substances SMD were 1.62 nmol/mL greater in cases than in controls (95% CI: 0.27, 2.96). The overall estimate SMD for serum vitamin E was 1.12 nmol/mL less in cases than controls (95% CI: -1.77, -0.48) and vitamin C SMD overall estimate was -0.53 (95%CI: -1.03, -0.02), significantly lower in cases compared with controls. The overall SMD for erythrocyte superoxide dismutase was -2.37 (95% CI: -4.76, 0.03), a marginally significant decrease in cases versus controls.Conclusions: Established preeclampsia is associated with increased concentrations of oxidative stress markers including lipid peroxidation products, and a reduction in antioxidant concentrations.Target Audience: Obstetricians & Gynecologists, Family PhysiciansLearning Objectives: After completion of this educational activity, the participant should be better able to describe the pattern of oxidative stress markers associated with preeclampsia, and interpret the available literature as it relates to oxidative stress and preeclampsia.