Clinical correlates of tuberculosis co-infection in HIV-infected children hospitalized in Peru.
Clinical correlates of tuberculosis co-infection in HIV-infected children hospitalized in Peru.
复制标题
秘鲁住院的艾滋病毒感染儿童结核病合并感染的临床相关性。
DOI：
10.1016/j.ijid.2005.06.012
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Gilman,RobertH
中科院分区：
文献类型：
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作者：
Ramirez-Cardich,MariaE;Kawai,Vivian;Oberhelman,RichardA;Bautista,ChristianT;Castillo,MariaE;Gilman,RobertH
在发展中国家，结核病（TB）每年造成近25万儿童死亡。感染人类免疫缺陷病毒（HIV）的儿童活动性结核病很难诊断，并迅速发展至死亡。本初步研究的目的是调查结核病相关疾病的患病率和临床相关性的艾滋病毒感染的儿童承认一个传染病病房在秘鲁，一个国家的结核病是高度流行的。方法47名艾滋病毒感染的儿童承认一个可疑的传染过程中，在秘鲁医院进行了调查的证据，临床结核病的金胺染色，培养，8名儿童（17%）有结核病证据，其中5名培养阳性，3名仅PCR检测阳性。体重减轻是唯一与结核病检测阳性相关的特征。放射学变化是非常常见的TB阳性和TB阴性组，这些变化是没有用的TB阳性cases.CONCLUSIONSWeight损失可用于确定高风险的HIV阳性儿童谁需要更积极的结核病评估。放射学改变在TB阳性和TB阴性组中均常见。
INTRODUCTIONIn developing countries, tuberculosis (TB) is responsible for almost 250000 deaths among children yearly. Active TB in children with human immunodeficiency virus (HIV) infection is difficult to diagnose and progresses rapidly to death. The aim of this preliminary study was to investigate the prevalence and clinical correlates of TB-related illness among HIV-infected children admitted to an infectious diseases ward in Peru, a country where TB is highly endemic.METHODForty-seven HIV-infected children admitted for a suspected infectious process in a Peruvian hospital were investigated for evidence of clinical tuberculosis by auramine stain, culture, and polymerase chain reaction (PCR) of clinical specimens.RESULTSEight children (17%) had evidence of tuberculosis, including five with positive cultures and three with positive PCR tests only. Weight loss was the only feature associated with a positive test for tuberculosis. Radiological changes were very common in both TB-positive and TB-negative groups and these changes were not useful to identify TB-positive cases.CONCLUSIONSWeight loss may be used to identify high-risk HIV positive children who require more aggressive evaluation for tuberculosis. Radiological changes were common in both TB-positive and TB-negative groups.