Heart of the matter: coronary dysfunction in metabolic syndrome.
Heart of the matter: coronary dysfunction in metabolic syndrome.
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DOI：
10.1016/j.yjmcc.2011.06.025
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发表时间：
2012-04
影响因子：
5
通讯作者：
Tune JD
中科院分区：
文献类型：
--
作者：
Berwick ZC;Dick GM;Tune JD
代谢综合征（MetS）是包括肥胖、血脂异常、胰岛素抵抗/葡萄糖耐量受损和/或高血压的风险因素的集合。肥胖症的发病率已达到流行水平，因为在大多数发达国家中约20-30%的成年人可被归类为患有MetS。MetS患病率的增加至关重要，因为它与心血管疾病风险的两倍升高相关。虽然这种疾病增加的病理生理学尚未明确定义，但最近的证据表明，冠状动脉血流控制的改变可能起着重要作用。这篇综述的目的是强调目前对MetS调节冠状动脉血流的作用的理解，并概述所涉及的潜在机制。特别是，通过交感神经α-肾上腺素受体和肾素-血管紧张素-醛固酮系统（RAAS）的神经体液调节的作用进行了探讨。末端效应K+，Ca 2+和瞬时受体电位（TRP）通道的贡献的变化也得到了解决。最后，未来的前景和潜在的治疗靶向微循环代谢综合征进行了讨论。
Metabolic syndrome (MetS) is a collection of risk factors including obesity, dyslipidemia, insulin resistance/impaired glucose tolerance, and/or hypertension. The incidence of obesity has reached pandemic levels, as ~20–30% of adults in most developed countries can be classified as having MetS. This increased prevalence of MetS is critical as it is associated with a two-fold elevated risk for cardiovascular disease. Although the pathophysiology underlying this increase in disease has not been clearly defined, recent evidence indicates that alterations in the control of coronary blood flow could play an important role. The purpose of this review is to highlight current understanding of the effects of MetS on regulation of coronary blood flow and to outline the potential mechanisms involved. In particular, the role of neurohumoral modulation via sympathetic α-adrenoceptors and the renin-angiotensin-aldosterone system (RAAS) are explored. Alterations in the contribution of end-effector K+, Ca2+, and transient receptor potential (TRP) channels are also addressed. Finally, future perspectives and potential therapeutic targeting of the microcirculation in MetS are discussed.
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影响因子：
3.3
作者：
Bowles, DK;Heaps, CL;Price, EM
通讯作者：
Price, EM
影响因子：
5
作者：
Berg, T
通讯作者：
Berg, T
DOI：
10.3181/0812-rm-350
发表时间：
2009-06
期刊：
Experimental biology and medicine (Maywood, N.J.)
影响因子：
--
作者：
Bender SB;Tune JD;Borbouse L;Long X;Sturek M;Laughlin MH
通讯作者：
Laughlin MH
DOI：
10.1152/ajpheart.00888.2009
发表时间：
2010-04-01
影响因子：
4.8
作者：
Borbouse, Lena;Dick, Gregory M.;Tune, Johnathan D.
通讯作者：
Tune, Johnathan D.
DOI：
10.1152/ajpheart.01053.2004
发表时间：
2005-09-01
影响因子：
4.8
作者：
Bratz, IN;Swafford, AN;Dick, GM
通讯作者：
Dick, GM