Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans
Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans
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DOI：
10.1177/153537020422900305
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发表时间：
2004-03-01
影响因子：
3.2
通讯作者：
Yoshikawa, T
中科院分区：
文献类型：
--
作者：
Takano, H;Osakabe, N;Yoshikawa, T
紫苏提取物富含迷迭香酸（一种多酚类植物化学物质），可抑制小鼠的过敏性免疫球蛋白反应和多形核白细胞（PMNL）引起的炎症。然而，很少有安慰剂对照临床试验研究了多酚类植物化学物质治疗人类过敏性炎症疾病的有效性和安全性。本研究确定口服迷迭香酸是否是季节性变应性鼻结膜炎（SAR）患者的有效干预措施。在这项为期21天的随机、双盲、年龄匹配、安慰剂对照平行组研究中，轻度SAR患者每天服用富含迷迭香酸的紫苏提取物（200 mg [n = 10]或50 mg [n = 9]）或安慰剂（n = 10）。病人每天在日记中记录症状。检测鼻腔灌洗液浸润细胞谱及eotaxin、il -1 β、IL-8、组胺浓度。血清IgE浓度和血常规也被检查。与安慰剂相比，补充富含迷迭香酸的紫苏提取物可显著提高鼻痒、眼痒、眼痒和总症状的缓解率（P < 0.05）。积极治疗显著降低了鼻灌洗液中中性粒细胞和嗜酸性粒细胞的数量（P < 0.05）。患者未报告不良事件，常规血液检查未发现明显异常。综上所述，紫苏提取物富集迷迭香酸可通过抑制PMNL向鼻孔的浸润而有效干预轻度SAR。使用这种替代治疗SAR可能会降低过敏性疾病的治疗费用。
Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, suppresses allergic immunoglobulin responses and inflammation caused by polymorphonuclear leukocytes (PMNL) in mice. However, few placebo-controlled clinical trials have examined the efficacy and safety of polyphenolic phytochemicals for treatment of allergic inflammatory diseases in humans. The present study determined whether oral supplementation with rosmarinic acid is an effective intervention for patients with seasonal allergic rhinoconjunctivitis (SAR). In this 21-day, randomized, double-blind, age-matched, placebo-controlled parallel group study, patients with mild SAR were treated daily with extract of Perilla frutescens enriched for rosmarinic acid (200 mg [n = 10] or 50 mg [n = 9]) or placebo (n = 10). Patients recorded symptoms daily in a diary. Profiles of infiltrating cells and concentrations of eotaxin, IL-1beta, IL-8, and histamine were measured in nasal lavage fluid. Serum IgE concentrations and routine blood tests were also examined. As compared with placebo supplementation, supplementation with extract of Perilla frutescens enriched for rosmarinic acid resulted in a significant increase in responder rates for itchy nose, watery eyes, itchy eyes, and total symptoms (P < 0.05). Active treatment significantly decreased the numbers of neutrophils and eosinophils in nasal lavage fluid (P < 0.05 vs. placebo). Patients reported no adverse events, and no significant abnormalities were detected in routine blood tests. In conclusion, extract of Perilla frutescens enriched for rosmarinic acid can be an effective intervention for mild SAR at least partly through inhibition of PMNL infiltration into the nostrils. Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases.