SNP rs2243828 in MPO associated with myeloperoxidase level and atrial fibrillation risk in Chinese Han population.
SNP rs2243828 in MPO associated with myeloperoxidase level and atrial fibrillation risk in Chinese Han population.
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MPO中的SNP rs2243828与中国汉族人群髓过氧化物酶水平和心房颤动风险相关
DOI：
10.1111/jcmm.15644
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发表时间：
2020-09
影响因子：
5.3
通讯作者：
Xu C
中科院分区：
文献类型：
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作者：
Wang P;Cheng M;Wang P;Xiong L;Zeng Y;Tu X;Zhang R;Xia Y;Wu G;Wang Q;Cheng X;Xu C
Previous studies shown that myeloperoxidase (MPO) level is higher in patients with atrial fibrillation (AF); however, no genetic evidence between MPO and AF risk in human population was observed. Therefore, the present study was aimed to investigate the association between rs2243828, a variant in promoter region of MPO and the risk of AF in Chinese GeneID population. The results demonstrated that the minor G allele of rs2243828 showed a significant association with AF in two independent population (GeneID‐north population with 694 AF cases and 710 controls, adjusted P‐adj = 6.25 × 10−3 with an odds ratio was 0.77, GeneID‐central population with 1106 cases and 1501 controls, P‐adj = 9.88 × 10−5 with an odds ratio was 0.75). The results also showed G allele was significantly associated with lower plasma concentration of myeloperoxidase in general population. We also observed a significant difference of odds ratio between subgroups of hypertension and non‐hypertension. Therefore, our findings identified variant in MPO associated with risk of AF and it may give strong evidence to link the inflammation with the incidence of AF.
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DOI：
10.1016/s0197-2456(98)00037-3
发表时间：
1998-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Dupont, WD;Plummer, WD
通讯作者：
Plummer, WD
基于候选通路的全基因组关联研究确定了与冠状动脉疾病相关的补体系统中基因组变异的新关联
DOI：
10.1161/circgenetics.114.000738
发表时间：
2014-12
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Xu C;Yang Q;Xiong H;Wang L;Cai J;Wang F;Li S;Chen J;Wang C;Wang D;Xiong X;Wang P;Zhao Y;Wang X;Huang Y;Chen S;Yin D;Li X;Liu Y;Liu J;Wang J;Li H;Ke T;Ren X;Wu Y;Wu G;Wan J;Zhang R;Wu T;Wang J;Xia Y;Yang Y;Cheng X;Liao Y;Chen Q;Zhou Y;He Q;Tu X;Wang QK
通讯作者：
Wang QK
影响因子：
2.8
作者：
Schnabel, Renate B.;Larson, Martin G.;Yamamoto, Jennifer F.;Kathiresan, Sekar;Rong, Jian;Levy, Daniel;Keaney, John F., Jr.;Wang, Thomas J.;Vasan, Ramachandran S.;Benjamin, Emelia J.
通讯作者：
Benjamin, Emelia J.
影响因子：
4
作者：
Friedrichs K;Baldus S;Klinke A
通讯作者：
Klinke A
影响因子：
82.9
作者：
通讯作者：
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