Effect of context exposure after fear learning on memory generalization in mice.
Effect of context exposure after fear learning on memory generalization in mice.
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DOI：
10.1186/s13041-015-0184-0
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发表时间：
2016-01-08
期刊：
影响因子：
3.6
通讯作者：
Sakaguchi M
中科院分区：
文献类型：
--
作者：
Fujinaka A;Li R;Hayashi M;Kumar D;Changarathil G;Naito K;Miki K;Nishiyama T;Lazarus M;Sakurai T;Kee N;Nakajima S;Wang SH;Sakaguchi M
记忆泛化发生的条件还没有很好的理解。虽然人们认为恐惧记忆的泛化是在学习后逐渐建立的，但不清楚学习后不久的经历是否会影响泛化。使用小鼠的情境恐惧条件化范式，我们发现当小鼠在恐惧学习后不久暴露于熟悉的无条件情境时，恐惧记忆泛化发生。我们的研究结果表明，熟悉的背景和他们的曝光时间影响记忆泛化，这增加了我们的理解泛化的机制。本文的在线版本（doi：10.1186/s13041-015-0184-0）包含补充材料，可供授权用户使用。
The conditions under which memory generalization occurs are not well understood. Although it is believed that fear memory generalization is gradually established after learning, it is not clear whether experiences soon after learning affect generalization. Using a contextual fear conditioning paradigm in mice, we found that fear memory generalization occurred when mice were exposed to a familiar, unconditioned context soon after fear learning. Our results suggest that the familiarity of contexts and the timing of their exposure influences memory generalization, which increases our understanding of the mechanisms of generalization. The online version of this article (doi:10.1186/s13041-015-0184-0) contains supplementary material, which is available to authorized users.