Vibrio cholerae O1 El Tor:: Identification of a gene cluster required for the rugose colony type, exopolysaccharide production, chlorine resistance, and biofilm formation
Vibrio cholerae O1 El Tor:: Identification of a gene cluster required for the rugose colony type, exopolysaccharide production, chlorine resistance, and biofilm formation
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DOI：
10.1073/pnas.96.7.4028
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发表时间：
1999-03-30
影响因子：
11.1
通讯作者：
Schoolnik, GK
中科院分区：
文献类型：
--
作者：
Yildiz, FH;Schoolnik, GK
霍乱弧菌O1的皱纹菌落变种，生物型El Tor，被证明能产生一种胞外多糖EPSETr，它具有耐氯性和生物被膜能力。EPSETr的产生需要一个染色体基因Vps，该基因包含与其他细菌物种的碳水化合物生物合成基因同源的序列，该基因座内的突变产生对氯敏感的平滑菌落变种，这些变异缺乏生物膜，EPSETr的生物被膜形成特性可能使霍乱弧菌O1在人类疾病爆发之间的环境水生生境中存活。
The rugose colony variant of Vibrio cholerae O1, biotype El Tor, is shown to produce an exopolysaccharide, EPSETr, that confers chlorine resistance and biofilm-forming capacity. EPSETr production requires a chromosomal locus, vps, that contains sequences homologous to carbohydrate biosynthesis genes of other bacterial species, Mutations within this locus yield chlorine-sensitive, smooth colony variants that are biofilm deficient, The biofilm-forming properties of EPSETr may enable the survival of V. cholerae O1 within environmental aquatic habitats between outbreaks of human disease.