Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models.
Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models.
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作者：
Hsu FL;Huang CF;Chen YW;Yen YP;Wu CT;Uang BJ;Yang RS;Liu SH
研究了小分子天然产物翼红素A对糖尿病的治疗作用。Pterosin A口服4周，有效改善链脲佐菌素、高脂肪饮食喂养和db/db糖尿病小鼠的高血糖和葡萄糖耐受不良。正常小鼠和糖尿病小鼠经紫蝶素A治疗4周后均无不良反应。Pterosin A显著逆转地塞米松-IR小鼠和db/db小鼠血清胰岛素和胰岛素抵抗（IR）升高。Pterosin A显著逆转糖尿病小鼠肌肉GLUT-4易位减少和肝脏磷酸烯醇丙酮酸羧基激酶（PEPCK）表达增加。Pterosin A还能显著逆转糖尿病小鼠肌肉中amp活化蛋白激酶（AMPK）和Akt磷酸化的下降。在db/db小鼠的肝脏中，AMPK磷酸化的降低和p38磷酸化的增加可以被pterosin A有效地逆转。pterosin A可以增强葡萄糖摄取和AMPK磷酸化。在培养的肝细胞中，pterosin A抑制诱导剂增强的PEPCK表达，触发AMPK、乙酰辅酶A羧化酶和糖原合成酶激酶-3的磷酸化，降低糖原合成酶磷酸化，增加细胞内糖原水平。这些发现表明翼色素A可能是糖尿病的潜在治疗选择。
The therapeutic effect of pterosin A, a small-molecular-weight natural product, on diabetes was investigated. Pterosin A, administered orally for 4 weeks, effectively improved hyperglycemia and glucose intolerance in streptozotocin, high-fat diet–fed, and db/db diabetic mice. There were no adverse effects in normal or diabetic mice treated with pterosin A for 4 weeks. Pterosin A significantly reversed the increased serum insulin and insulin resistance (IR) in dexamethasone-IR mice and in db/db mice. Pterosin A significantly reversed the reduced muscle GLUT-4 translocation and the increased liver phosphoenolpyruvate carboxyl kinase (PEPCK) expression in diabetic mice. Pterosin A also significantly reversed the decreased phosphorylations of AMP-activated protein kinase (AMPK) and Akt in muscles of diabetic mice. The decreased AMPK phosphorylation and increased p38 phosphorylation in livers of db/db mice were effectively reversed by pterosin A. Pterosin A enhanced glucose uptake and AMPK phosphorylation in cultured human muscle cells. In cultured liver cells, pterosin A inhibited inducer-enhanced PEPCK expression, triggered the phosphorylations of AMPK, acetyl CoA carboxylase, and glycogen synthase kinase-3, decreased glycogen synthase phosphorylation, and increased the intracellular glycogen level. These findings indicate that pterosin A may be a potential therapeutic option for diabetes.
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DOI：
10.1152/ajprenal.00097.2002
发表时间：
2002-10-01
影响因子：
4.2
作者：
Feifel, E;Obexer, P;Gstraunthaler, G
通讯作者：
Gstraunthaler, G
影响因子：
7.7
作者：
Chen, Ya Wen;Huang, Chun Fa;Liu, Shing Hwa
通讯作者：
Liu, Shing Hwa
影响因子：
4.8
作者：
Cao, WH;Collins, QF;Collins, S
通讯作者：
Collins, S
影响因子：
4.8
作者：
Berasi, Stephen P.;Huard, Christine;Martinez, Robert V.
通讯作者：
Martinez, Robert V.
影响因子：
6.1
作者：
Huang, Chun Fa;Chen, Ya Wen;Liu, Shing Hwa
通讯作者：
Liu, Shing Hwa