Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?
Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?
复制标题
针对促癌炎症——抗炎疗法已经成熟了吗？
DOI：
10.1038/s41571-020-00459-9
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Sun B
中科院分区：
文献类型：
--
作者：
Hou J;Karin M;Sun B
免疫系统在癌症的发展和治疗中发挥着至关重要的作用。尽管适应性免疫可以通过免疫监视来预防或抑制癌症，但先天免疫和炎症通常会促进新生癌症的肿瘤发生和恶性进展。在过去的十年中，我们见证了从抗肿瘤免疫的临床前研究中获得的知识转化为临床有效的、批准的癌症免疫疗法。相比之下，针对癌症相关炎症的治疗方法的成功实施仍在等待。抗炎剂不仅有可能预防或延迟癌症发作，而且还可以提高常规治疗和下一代免疫治疗的疗效。在此，我们回顾了目前的临床进展和实验结果，支持实用的抗炎方法来治疗实体恶性肿瘤。更好地理解抗炎药的作用机制并设计更有效的治疗组合将促进这种治疗方法的临床应用。
The immune system has crucial roles in cancer development and treatment. Whereas adaptive immunity can prevent or constrain cancer through immunosurveillance, innate immunity and inflammation often promote tumorigenesis and malignant progression of nascent cancer. The past decade has witnessed the translation of knowledge derived from preclinical studies of antitumour immunity into clinically effective, approved immunotherapies for cancer. By contrast, the successful implementation of treatments that target cancer-associated inflammation is still awaited. Anti-inflammatory agents have the potential to not only prevent or delay cancer onset but also to improve the efficacy of conventional therapeutics and next-generation immunotherapies. Herein, we review the current clinical advances and experimental findings supporting the utility of an anti-inflammatory approach to the treatment of solid malignancies. Gaining a better mechanistic understanding of the mode of action of anti-inflammatory agents and designing more effective treatment combinations would advance the clinical application of this therapeutic approach.
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影响因子：
64.5
作者：
Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu;Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network
DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
158.5
作者：
Bertagnolli, Monica M.;Eagle, Craig J.;Hawk, Ernest T.
通讯作者：
Hawk, Ernest T.
影响因子：
50.5
作者：
Bosetti, C.;Santucci, C.;La Vecchia, C.
通讯作者：
La Vecchia, C.
影响因子：
45.3
作者：
Borchmann, Sven;Cirillo, Melita;Engert, Andreas
通讯作者：
Engert, Andreas