Phrenic activity, respiratory pressures, and volume changes in cats.
Phrenic activity, respiratory pressures, and volume changes in cats.
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猫的膈活动、呼吸压力和体积变化。
DOI：
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发表时间：
1981
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通讯作者：
J. Milic‐Emili
中科院分区：
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作者：
N. Siafakas;R. Peslin;M. Bonora;H. Gautier;B. Duron;J. Milic‐Emili
在8只麻醉猫中，我们测量了在室内空气呼吸、缺氧和高碳酸血症期间的综合（“移动时间平均”）膈活动[使用膈神经电图（EPHR）]和主动跨膜压[Pdi（mus）]。Pdi（mus）和EPHR之间的关系是不受缺氧或高碳酸刺激的呼吸，这表明在自主呼吸猫的压力损失是可以忽略不计的。然而，在所有猫中，Pdi（mus）均出现显著的容积相关性降低，表明随着肺容积的增加，隔膜作为压力发生器的有效性降低。此外，我们已经开发了一个模型，允许预测的时间过程中的变化，肺容量的吸气驱动压力的不同形态。这个模型解释了在我们的猫身上实验发现的呼吸控制的许多特征。
In eight anesthetized cats we measured the integrated ("moving time average") phrenic activity [using phrenic electroneurogram (EPHR)] and the active transdiaphragmatic pressure [Pdi(mus)] during room air breathing, hypoxia, and hypercapnia. The relationship between Pdi(mus) and EPHR was unaffected by either hypoxic or hypercapnic stimulation of breathing, suggesting that in spontaneously breathing cats the pressure losses are negligible. In all cats, however, there was a substantial volume-related decrease in Pdi(mus), indicating that with increasing lung volume the effectiveness of the diaphragm as a pressure generator decreases. In addition, we have developed a model that allows prediction of the time course changes in lung volume for different morphology of inspiratory driving pressure. This model explains many of the features of control of breathing found experimentally in our cats.